STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_2196Competence protein ComEA helix-hairpin-helix repeat protein; COGs: COG1555 DNA uptake protein and related DNA-binding protein; InterPro IPR003583: IPR019554: IPR004509; KEGG: sth:STH455 putative DNA-binding protein; PFAM: Soluble ligand binding domain; SMART: Helix-hairpin-helix DNA-binding class 1; SPTR: Putative DNA-binding protein; TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; PFAM: SLBB domain; Helix-hairpin-helix motif; TIGRFAM: competence protein ComEA helix-hairpin-helix repeat region; comEA protein. (360 aa)    
Predicted Functional Partners:
Tmar_2195
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477: IPR000408: IPR004797; KEGG: sth:STH473 ComE-like competence protein; PFAM: ComEC/Rec2-related protein; SPTR: ComE-like competence protein; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
 
  
 0.892
Tmar_0665
COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076: IPR003004: IPR001992; KEGG: dau:Daud_0970 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: Type II secretion system protein; PFAM: Bacterial type II secretion system protein F domain.
  
  
 0.781
Tmar_0664
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR007831: IPR001482: IPR003593; KEGG: dtu:Dtur_0873 general secretory pathway protein E; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; SMART: AAA ATPase; SPTR: General secretory pathway protein E; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT.
  
  
 0.719
Tmar_0663
Prepilin peptidase; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627: IPR000045: IPR000530; KEGG: rxy:Rxyl_1154 peptidase A24A-like protein; PFAM: peptidase A24A domain protein; peptidase A24A prepilin type IV; PRIAM: Prepilin peptidase; SPTR: Peptidase A24A-like protein; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family.
   
  
 0.673
Tmar_0738
Cell envelope-related transcriptional attenuator; COGs: COG1316 Transcriptional regulator; InterPro IPR017909: IPR004474; KEGG: chy:CHY_2591 putative transcriptional regulator; PFAM: cell envelope-related transcriptional attenuator; SPTR: Cell envelope-related transcriptional attenuator; TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: Cell envelope-related transcriptional attenuator domain; TIGRFAM: cell envelope-related function transcriptional attenuator common domain.
 
     0.663
Tmar_2354
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
 
  
 0.603
Tmar_2199
COGs: COG1316 Transcriptional regulator; InterPro IPR004474; KEGG: hor:Hore_13390 cell envelope-related transcriptional attenuator; PFAM: cell envelope-related transcriptional attenuator; SPTR: Cell envelope-related transcriptional attenuator; TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: Cell envelope-related transcriptional attenuator domain; TIGRFAM: cell envelope-related function transcriptional attenuator common domain.
 
     0.572
cinA
Competence/damage-inducible protein CinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135: IPR008136: IPR001453; KEGG: sth:STH1643 competence damage-inducible protein A; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: Putative competence-damage inducible protein; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal doma [...]
     
 0.509
Tmar_2194
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372: IPR005790; KEGG: pth:PTH_0867 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
 
     0.503
Tmar_0191
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: dds:Ddes_1733 ComF family protein; PFAM: phosphoribosyltransferase; SPTR: ComF family protein; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
  
  
 0.475
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.