STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmar_2328COGs: COG4463 Transcriptional repressor of class III stress genes; InterPro IPR008463; KEGG: sth:STH3136 transcriptional repressor of class III stress genes; PFAM: Firmicute transcriptional repressor of class III stress genes; SPTR: Transcriptional repressor of class III stress genes; PFAM: Firmicute transcriptional repressor of class III stress genes (CtsR). (181 aa)    
Predicted Functional Partners:
Tmar_2327
UvrB/UvrC protein; COGs: COG3880 Uncharacterized protein with conserved CXXC pairs; InterPro IPR001943; KEGG: pth:PTH_0281 hypothetical protein; PFAM: UvrB/UvrC protein; SPTR: Uncharacterized protein; PFAM: UvrB/uvrC motif.
 
  
 0.989
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
 
  
 0.980
Tmar_2325
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR001943: IPR001270: IPR003593: IPR004176: IPR 003959: IPR013093: IPR019489: IPR018368; KEGG: sth:STH3133 class III stress response-related ATPase; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: Class III stress response-related ATPase; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associ [...]
  
  
 0.949
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.637
Tmar_0956
Helix-turn-helix protein YlxM/p13 family protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
  
     0.590
Tmar_2318
COGs: COG4956 Integral membrane protein (PIN domain superfamily); InterPro IPR002792: IPR006596: IPR002716: IPR000944; KEGG: mta:Moth_2488 PilT protein-like; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc; SPTR: PilT protein domain protein; PFAM: TRAM domain; PIN domain.
 
    0.587
disA
DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
  
  
 0.567
Tmar_0945
Regulatory protein DeoR; InterPro IPR001034; KEGG: sth:STH1446 fatty acid biosynthesis transcriptional regulator; PFAM: regulatory protein DeoR; SPTR: Putative uncharacterized protein.
  
     0.498
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.461
Tmar_2329
COGs: COG3653 N-acyl-D-aspartate/D-glutamate deacylase; InterPro IPR006680: IPR012855; KEGG: sth:STH3170 D-aminoacylase; PFAM: D-aminoacylase domain protein; amidohydrolase; PRIAM: N-acyl-D-glutamate deacylase; SPTR: D-Aminoacylase; PFAM: D-aminoacylase, C-terminal region; Amidohydrolase family.
       0.460
Your Current Organism:
Thermaerobacter marianensis
NCBI taxonomy Id: 644966
Other names: T. marianensis DSM 12885, Thermaerobacter marianensis 7p75a, Thermaerobacter marianensis ATCC 700841, Thermaerobacter marianensis DSM 12885, Thermaerobacter marianensis str. DSM 12885, Thermaerobacter marianensis strain DSM 12885
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