node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACR18139.1 | ACR18141.1 | ckrop_1399 | ckrop_1401 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | 0.618 |
ACR18139.1 | ACR18143.1 | ckrop_1399 | ckrop_1403 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein. | 0.530 |
ACR18139.1 | murI | ckrop_1399 | ckrop_1402 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.947 |
ACR18139.1 | rph | ckrop_1399 | ckrop_1400 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.982 |
ACR18141.1 | ACR18139.1 | ckrop_1401 | ckrop_1399 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.618 |
ACR18141.1 | ACR18143.1 | ckrop_1401 | ckrop_1403 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Conserved hypothetical protein. | 0.669 |
ACR18141.1 | ACR18144.1 | ckrop_1401 | ckrop_1404 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Putative nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.416 |
ACR18141.1 | ACR18145.1 | ckrop_1401 | ckrop_1405 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Putative ATP-dependent DNA helicase. | 0.453 |
ACR18141.1 | cya | ckrop_1401 | ckrop_1977 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Adenylate cyclase. | 0.797 |
ACR18141.1 | glxR | ckrop_1401 | ckrop_2008 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Transcriptional regulator, Crp family. | 0.435 |
ACR18141.1 | murI | ckrop_1401 | ckrop_1402 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.669 |
ACR18141.1 | pafA1 | ckrop_1401 | ckrop_0912 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Proteasomal accessory factor. | 0.421 |
ACR18141.1 | pafA2 | ckrop_1401 | ckrop_0910 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Proteasomal accessory factor; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.411 |
ACR18141.1 | rph | ckrop_1401 | ckrop_1400 | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.822 |
ACR18143.1 | ACR18139.1 | ckrop_1403 | ckrop_1399 | Conserved hypothetical protein. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.530 |
ACR18143.1 | ACR18141.1 | ckrop_1403 | ckrop_1401 | Conserved hypothetical protein. | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | 0.669 |
ACR18143.1 | murI | ckrop_1403 | ckrop_1402 | Conserved hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.842 |
ACR18143.1 | rph | ckrop_1403 | ckrop_1400 | Conserved hypothetical protein. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.623 |
ACR18144.1 | ACR18141.1 | ckrop_1404 | ckrop_1401 | Putative nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Hypothetical protein; Metal-dependent hydrolases of the beta- lactamase superfamily III. | 0.416 |
ACR18144.1 | ACR18145.1 | ckrop_1404 | ckrop_1405 | Putative nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Putative ATP-dependent DNA helicase. | 0.804 |