node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | SPPG_00032 | A0A0L0HRF8 | A0A0L0HTV3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku domain-containing protein. | 0.685 |
FEN1 | SPPG_00780 | A0A0L0HRF8 | A0A0L0HUU2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | HIT domain-containing protein. | 0.596 |
FEN1 | SPPG_00834 | A0A0L0HRF8 | A0A0L0HUZ5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.852 |
FEN1 | SPPG_03918 | A0A0L0HRF8 | A0A0L0HH69 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | HIT domain-containing protein. | 0.596 |
FEN1 | SPPG_05936 | A0A0L0HRF8 | A0A0L0HD90 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATP-dependent DNA helicase II, 70 kDa subunit (Ku70). | 0.743 |
FEN1 | SPPG_06135 | A0A0L0HRF8 | A0A0L0HBW4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ZnF_Rad18 domain-containing protein. | 0.983 |
FEN1 | SPPG_07693 | A0A0L0HRF8 | A0A0L0H7I9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | PCNA_C domain-containing protein. | 0.963 |
FEN1 | SPPG_08543 | A0A0L0HRF8 | A0A0L0H3V4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.887 |
SPPG_00032 | FEN1 | A0A0L0HTV3 | A0A0L0HRF8 | Ku domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.685 |
SPPG_00032 | SPPG_00077 | A0A0L0HTV3 | A0A0L0HSK6 | Ku domain-containing protein. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.989 |
SPPG_00032 | SPPG_00780 | A0A0L0HTV3 | A0A0L0HUU2 | Ku domain-containing protein. | HIT domain-containing protein. | 0.634 |
SPPG_00032 | SPPG_00834 | A0A0L0HTV3 | A0A0L0HUZ5 | Ku domain-containing protein. | DNA ligase. | 0.984 |
SPPG_00032 | SPPG_03918 | A0A0L0HTV3 | A0A0L0HH69 | Ku domain-containing protein. | HIT domain-containing protein. | 0.634 |
SPPG_00032 | SPPG_05936 | A0A0L0HTV3 | A0A0L0HD90 | Ku domain-containing protein. | ATP-dependent DNA helicase II, 70 kDa subunit (Ku70). | 0.999 |
SPPG_00032 | SPPG_06135 | A0A0L0HTV3 | A0A0L0HBW4 | Ku domain-containing protein. | ZnF_Rad18 domain-containing protein. | 0.999 |
SPPG_00032 | SPPG_07693 | A0A0L0HTV3 | A0A0L0H7I9 | Ku domain-containing protein. | PCNA_C domain-containing protein. | 0.464 |
SPPG_00032 | SPPG_08543 | A0A0L0HTV3 | A0A0L0H3V4 | Ku domain-containing protein. | Uncharacterized protein. | 0.804 |
SPPG_00032 | SPPG_09270 | A0A0L0HTV3 | A0A0L0HGB4 | Ku domain-containing protein. | Uncharacterized protein. | 0.948 |
SPPG_00077 | SPPG_00032 | A0A0L0HSK6 | A0A0L0HTV3 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Ku domain-containing protein. | 0.989 |
SPPG_00077 | SPPG_00780 | A0A0L0HSK6 | A0A0L0HUU2 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | HIT domain-containing protein. | 0.611 |