A0A1Y2GBB3 protein (Lobosporangium transversale)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1Y2GBB3

Uncharacterized protein. (108 aa)

Predicted Functional Partners:

A0A1Y2G8B9

0.673

A0A1Y2GCZ2

0.631

A0A1Y2GI43

0.631

A0A1Y2GLW0

0.631

A0A1Y2GMD2

0.631

A0A1Y2GST6

0.631

A0A1Y2H3D7

0.631

A0A1Y2GJ68

0.610

A0A1Y2G747

0.606

A0A1Y2G844

0.606

Your Current Organism:

Lobosporangium transversale

NCBI taxonomy Id: 64571
Other names: ATCC 16960, CBS 357.67, Echinosporangium transversale, IMI 130776ii, L. transversale, NRRL 3116

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2G747	A0A1Y2GBB3	Integral peroxisomal membrane peroxin-domain-containing protein.	Uncharacterized protein.	0.606
A0A1Y2G747	A0A1Y2GCZ2	Integral peroxisomal membrane peroxin-domain-containing protein.	Uncharacterized membrane protein.	0.694
A0A1Y2G747	A0A1Y2GI43	Integral peroxisomal membrane peroxin-domain-containing protein.	Nudix hydrolase domain-containing protein.	0.694
A0A1Y2G747	A0A1Y2GLW0	Integral peroxisomal membrane peroxin-domain-containing protein.	Clasp N terminal-domain-containing protein.	0.694
A0A1Y2G747	A0A1Y2GMD2	Integral peroxisomal membrane peroxin-domain-containing protein.	Uncharacterized protein.	0.694
A0A1Y2G747	A0A1Y2GST6	Integral peroxisomal membrane peroxin-domain-containing protein.	Uncharacterized protein.	0.694
A0A1Y2G747	A0A1Y2H3D7	Integral peroxisomal membrane peroxin-domain-containing protein.	NUDIX hydrolase domain-like protein; Belongs to the Nudix hydrolase family.	0.694
A0A1Y2G844	A0A1Y2GBB3	Uncharacterized protein.	Uncharacterized protein.	0.606
A0A1Y2G844	A0A1Y2GCZ2	Uncharacterized protein.	Uncharacterized membrane protein.	0.694
A0A1Y2G844	A0A1Y2GI43	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.694
A0A1Y2G844	A0A1Y2GLW0	Uncharacterized protein.	Clasp N terminal-domain-containing protein.	0.694
A0A1Y2G844	A0A1Y2GMD2	Uncharacterized protein.	Uncharacterized protein.	0.694
A0A1Y2G844	A0A1Y2GST6	Uncharacterized protein.	Uncharacterized protein.	0.694
A0A1Y2G844	A0A1Y2H3D7	Uncharacterized protein.	NUDIX hydrolase domain-like protein; Belongs to the Nudix hydrolase family.	0.694
A0A1Y2G8B9	A0A1Y2GBB3	Putative ubiquitin--protein ligase hus5; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.673
A0A1Y2GBB3	A0A1Y2G747	Uncharacterized protein.	Integral peroxisomal membrane peroxin-domain-containing protein.	0.606
A0A1Y2GBB3	A0A1Y2G844	Uncharacterized protein.	Uncharacterized protein.	0.606
A0A1Y2GBB3	A0A1Y2G8B9	Uncharacterized protein.	Putative ubiquitin--protein ligase hus5; Belongs to the ubiquitin-conjugating enzyme family.	0.673
A0A1Y2GBB3	A0A1Y2GCZ2	Uncharacterized protein.	Uncharacterized membrane protein.	0.631
A0A1Y2GBB3	A0A1Y2GI43	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.631

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.832

expected number of edges:

11

PPI enrichment p-value:

2.69e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051231

Spindle elongation

9 of 18

3.68

15.08

2.98e-28

GO:0090307

Mitotic spindle assembly

9 of 29

3.47

14.26

5.19e-27

GO:0007018

Microtubule-based movement

11 of 206

2.71

12.55

5.19e-27

GO:0000070

Mitotic sister chromatid segregation

9 of 120

2.86

11.01

2.02e-22

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

9 of 44

3.29

13.54

5.17e-26

GO:0003777

Microtubule motor activity

11 of 183

2.76

12.96

1.74e-27

GO:0008017

Microtubule binding

11 of 499

2.32

9.35

2.16e-23

GO:0005524

ATP binding

11 of 10499

1.0

1.25

3.04e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072686

Mitotic spindle

9 of 48

3.25

13.33

1.06e-25

GO:0005876

Spindle microtubule

9 of 80

3.03

12.2

3.73e-24

GO:0005874

Microtubule

11 of 607

2.24

8.69

8.18e-23

GO:0005737

Cytoplasm

10 of 38115

0.4

0.3

0.0168

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:145257

Kinesin motor domain, conserved site, and Plus-end directed microtubule sliding

8 of 59

3.11

10.29

4.49e-20

CL:145259

Mixed, incl. Spindle elongation, and Microtubule depolymerization

7 of 45

3.17

9.5

2.02e-18

CL:145261

Mixed, incl. Spindle elongation, and Kinesin-like protein KIF15/KIN-12

6 of 37

3.19

8.03

1.45e-15

CL:145263

Mixed, incl. Spindle elongation, and Regulation of spindle assembly

4 of 20

3.28

5.06

6.25e-10

CL:145264

Mixed, incl. Spindle elongation, and Regulation of spindle assembly

3 of 12

3.38

3.6

3.15e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

10 of 1052

1.96

5.82

1.83e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

10 of 164

2.77

11.77

1.15e-24

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

10 of 363

2.42

9.24

1.35e-21

MAP-8856688

Golgi-to-ER retrograde transport

10 of 467

2.31

8.44

1.08e-20

MAP-983231

Factors involved in megakaryocyte development and platelet production

10 of 531

2.25

8.04

2.89e-20

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

10 of 567

2.23

7.85

4.43e-20

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005876

Spindle microtubule

9 of 33

3.42

14.06

9.48e-27

GOCC:0015630

Microtubule cytoskeleton

10 of 944

2.01

6.12

9.42e-18

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

11 of 214

2.69

12.73

1.21e-27

KW-0067

ATP-binding

11 of 5170

1.31

2.29

7.38e-13

KW-0175

Coiled coil

10 of 10941

0.94

1.07

1.34e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047149

Kinesin-like protein KIF11-like

9 of 15

3.76

15.27

1.58e-28

IPR001752

Kinesin motor domain

11 of 160

2.82

13.34

7.21e-28

IPR036961

Kinesin motor domain superfamily

11 of 192

2.74

12.75

3.34e-27

IPR047241

Kinesin-like protein KIF11-like, kinesin motor domain

7 of 10

3.83

11.8

4.32e-22

IPR019821

Kinesin motor domain, conserved site

9 of 99

2.94

11.3

1.18e-22

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

11 of 160

2.82

13.71

1.01e-28

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