node1 | node2 | node1 annotation | node2 annotation | score |
A0A1Y2G708 | A0A1Y2G7T1 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.926 |
A0A1Y2G708 | A0A1Y2G8K3 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.989 |
A0A1Y2G708 | A0A1Y2GFE6 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.961 |
A0A1Y2G708 | A0A1Y2GIN0 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase. | 0.964 |
A0A1Y2G708 | A0A1Y2GSB1 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Adenosine kinase. | 0.814 |
A0A1Y2G708 | A0A1Y2GWL6 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Histidine biosynthesis trifunctional protein. | 0.911 |
A0A1Y2G708 | A0A1Y2H073 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Amidophosphoribosyltransferase. | 0.991 |
A0A1Y2G708 | A0A1Y2H169 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | CobB/CobQ-like glutamine amidotransferase domain-domain-containing protein. | 0.981 |
A0A1Y2G708 | A0A1Y2H568 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.815 |
A0A1Y2G7T1 | A0A1Y2G708 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.926 |
A0A1Y2G7T1 | A0A1Y2G8K3 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.931 |
A0A1Y2G7T1 | A0A1Y2GFE6 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.984 |
A0A1Y2G7T1 | A0A1Y2GFS0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | UreD urease accessory protein-domain-containing protein. | 0.922 |
A0A1Y2G7T1 | A0A1Y2GIN0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Phosphoribosylaminoimidazole-succinocarboxamide synthase. | 0.663 |
A0A1Y2G7T1 | A0A1Y2GSB1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenosine kinase. | 0.796 |
A0A1Y2G7T1 | A0A1Y2GWL6 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Histidine biosynthesis trifunctional protein. | 0.425 |
A0A1Y2G7T1 | A0A1Y2H073 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Amidophosphoribosyltransferase. | 0.844 |
A0A1Y2G7T1 | A0A1Y2H169 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | CobB/CobQ-like glutamine amidotransferase domain-domain-containing protein. | 0.690 |
A0A1Y2G7T1 | A0A1Y2H568 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.907 |
A0A1Y2G8K3 | A0A1Y2G708 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.989 |