A0A1Y2GIZ7 protein (Lobosporangium transversale)

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Predicted Interactions

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A0A1Y2GIZ7

Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)

Predicted Functional Partners:

A0A1Y2GN08

0.927

TRM8

0.772

A0A1Y2H4F2

0.755

A0A1Y2H7F7

0.674

A0A1Y2GUK8

0.506

A0A1Y2GW02

0.489

A0A1Y2FYV6

0.417

A0A1Y2H1A6

0.417

Your Current Organism:

Lobosporangium transversale

NCBI taxonomy Id: 64571
Other names: ATCC 16960, CBS 357.67, Echinosporangium transversale, IMI 130776ii, L. transversale, NRRL 3116

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y2FYV6	A0A1Y2GIZ7	A0A1Y2FYV6	A0A1Y2GIZ7	Mitochondrial carrier domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.417
A0A1Y2GIZ7	A0A1Y2FYV6	A0A1Y2GIZ7	A0A1Y2FYV6	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial carrier domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.417
A0A1Y2GIZ7	A0A1Y2GN08	A0A1Y2GIZ7	A0A1Y2GN08	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	AA_TRNA_LIGASE_II domain-containing protein.	0.927
A0A1Y2GIZ7	A0A1Y2GUK8	A0A1Y2GIZ7	A0A1Y2GUK8	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	RBR-type E3 ubiquitin transferase.	0.506
A0A1Y2GIZ7	A0A1Y2GW02	A0A1Y2GIZ7	A0A1Y2GW02	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	RBR-type E3 ubiquitin transferase.	0.489
A0A1Y2GIZ7	A0A1Y2H1A6	A0A1Y2GIZ7	A0A1Y2H1A6	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial carrier domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.417
A0A1Y2GIZ7	A0A1Y2H4F2	A0A1Y2GIZ7	A0A1Y2H4F2	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	AA_TRNA_LIGASE_II domain-containing protein.	0.755
A0A1Y2GIZ7	A0A1Y2H7F7	A0A1Y2GIZ7	A0A1Y2H7F7	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uncharacterized protein.	0.674
A0A1Y2GIZ7	TRM8	A0A1Y2GIZ7	A0A1Y2GRZ7	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	0.772
A0A1Y2GN08	A0A1Y2GIZ7	A0A1Y2GN08	A0A1Y2GIZ7	AA_TRNA_LIGASE_II domain-containing protein.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.927
A0A1Y2GN08	A0A1Y2H4F2	A0A1Y2GN08	A0A1Y2H4F2	AA_TRNA_LIGASE_II domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.746
A0A1Y2GUK8	A0A1Y2GIZ7	A0A1Y2GUK8	A0A1Y2GIZ7	RBR-type E3 ubiquitin transferase.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.506
A0A1Y2GW02	A0A1Y2GIZ7	A0A1Y2GW02	A0A1Y2GIZ7	RBR-type E3 ubiquitin transferase.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.489
A0A1Y2H1A6	A0A1Y2GIZ7	A0A1Y2H1A6	A0A1Y2GIZ7	Mitochondrial carrier domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.417
A0A1Y2H4F2	A0A1Y2GIZ7	A0A1Y2H4F2	A0A1Y2GIZ7	AA_TRNA_LIGASE_II domain-containing protein.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.755
A0A1Y2H4F2	A0A1Y2GN08	A0A1Y2H4F2	A0A1Y2GN08	AA_TRNA_LIGASE_II domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.746
A0A1Y2H7F7	A0A1Y2GIZ7	A0A1Y2H7F7	A0A1Y2GIZ7	Uncharacterized protein.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.674
TRM8	A0A1Y2GIZ7	A0A1Y2GRZ7	A0A1Y2GIZ7	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	Putative MRS4-protein of the mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.772

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.397

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

11 of 211

1.75

4.55

2.81e-16

GO:0006360

Transcription by RNA polymerase I

5 of 26

2.32

3.94

1.11e-08

GO:0006383

Transcription by RNA polymerase III

4 of 22

2.29

3.06

9.35e-07

GO:0006366

Transcription by RNA polymerase II

6 of 107

1.78

2.9

5.56e-08

GO:0045948

Positive regulation of translational initiation

2 of 4

2.73

1.55

0.0015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

7 of 23

2.52

6.33

1.65e-13

GO:0003677

DNA binding

8 of 627

1.14

1.34

2.49e-06

GO:0031369

Translation initiation factor binding

2 of 9

2.38

1.23

0.0053

GO:0003676

Nucleic acid binding

9 of 1284

0.88

0.87

1.71e-05

GO:1901363

Heterocyclic compound binding

10 of 2553

0.63

0.53

0.00031

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

11 of 82

2.16

7.81

3.17e-21

GO:0055029

Nuclear DNA-directed RNA polymerase complex

10 of 77

2.15

7.12

6.13e-19

GO:0005665

RNA polymerase II, core complex

6 of 13

2.7

6.4

3.90e-13

GO:0005736

RNA polymerase I complex

5 of 13

2.62

5.04

1.89e-10

GO:0005666

RNA polymerase III complex

5 of 16

2.53

4.82

3.67e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2800

RNA polymerase III complex, and RNA Polymerase I Transcription Initiation

7 of 26

2.46

6.33

9.93e-14

CL:2596

DNA-directed RNA polymerase complex, and TP53 Regulates Transcription of DNA Repair Genes

11 of 134

1.95

6.01

1.16e-18

CL:2806

RNA polymerase III complex

5 of 7

2.89

5.48

5.77e-11

CL:2716

RNA polymerase II, core complex

4 of 9

2.68

3.85

5.87e-08

CL:2840

RNA polymerase I activity, and RNA polymerase Rpb1, domain 5

2 of 5

2.63

1.5

0.0018

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

11 of 43

2.44

10.44

8.86e-25

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

6 of 26

2.4

5.06

5.13e-11

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

6 of 26

2.4

5.06

5.13e-11

MAP-76046

RNA Polymerase III Transcription Initiation

6 of 27

2.38

5.03

5.13e-11

MAP-74158

RNA Polymerase III Transcription

6 of 27

2.38

5.03

5.13e-11

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

6 of 30

2.33

4.97

5.13e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

10 of 84

2.11

6.66

6.60e-18

GOCC:0005736

RNA polymerase I complex

2 of 7

2.49

1.34

0.0035

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

3 of 61

1.72

1.2

0.0034

GOCC:0032991

Protein-containing complex

11 of 2362

0.7

0.67

3.40e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

8 of 20

2.63

8.35

1.29e-17

KW-0548

Nucleotidyltransferase

3 of 25

2.11

1.93

0.00016

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04998

RNA polymerase Rpb1, domain 5

2 of 2

3.03

1.28

0.0050

PF05000

RNA polymerase Rpb1, domain 4

2 of 3

2.86

1.27

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045867

DNA-directed RNA polymerase, subunit beta-prime

2 of 3

2.86

0.9

0.0233

IPR045113

RNA polymerase subunit Rpb7-like

2 of 3

2.86

0.9

0.0233

IPR044893

RNA polymerase Rpb1, clamp domain superfamily

2 of 3

2.86

0.9

0.0233

IPR042102

RNA polymerase Rpb1, domain 3 superfamily

2 of 3

2.86

0.9

0.0233

IPR038120

RNA polymerase Rpb1, funnel domain superfamily

2 of 3

2.86

0.9

0.0233

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00663

RNA polymerase I subunit A N-terminus

2 of 3

2.86

1.43

0.0026

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