STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
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[Homology]
Score
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
gcvP
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.959
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 
 0.951
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
   
 0.939
SMB91099.1
Dihydrolipoamide dehydrogenase; InterPro IPR003042:IPR013027:IPR000103:IPR000815:IPR001327:IPR0040 99:IPR002218:IPR006076:IPR012999:IPR006258; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); KEGG: pla:Plav_3138 dihydrolipoamide dehydrogenase; SPTR: A4CND5 Dihydrolipoyl dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; FAD dependent oxidoreductase; TIGRFAM: dihydrolipoamide dehydrogenase.
 
  
 0.931
SMB94831.1
Dihydrolipoamide dehydrogenase; InterPro IPR013027:IPR000103:IPR000815:IPR001327:IPR004099:IPR0022 18:IPR004792:IPR003953:IPR012999:IPR006258; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); KEGG: acr:Acry_1621 dihydrolipoamide dehydrogenase; SPTR: A3I207 Dihydrolipoyl dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein; fumarate reductase/succinate dehydrogenase flavoprotein domain [...]
 
  
 0.929
SMB94851.1
2-oxoglutarate dehydrogenase, E1 subunit; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; InterPro IPR001017:IPR005475:IPR011603; COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); KEGG: rce:RC1_2264 2-oxoglutarate dehydrogenase, E1 component; SPTR: A3I204 Alpha-ketoglutarate decarboxylase; PFAM: Transketolase central region; dehydrogenase E1 component.
   
 
 0.923
SMB99170.1
Transketolase central region; InterPro IPR005476:IPR001017:IPR005475; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; KEGG: sus:Acid_3687 dehydrogenase, E1 component; SPTR: A3U7B7 2-oxoisovalerate dehydrogenase, E1 component, alpha and beta subunit; PFAM: Transketolase central region; Transketolase domain protein; dehydrogenase E1 component.
   
 
 0.918
SMC00533.1
Transketolase domain protein; InterPro IPR005476:IPR001017:IPR005475; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; KEGG: hypothetical protein; SPTR: A1ZGW0 (Pyruvate) Oxoisovalerate Dehydrogenase Alpha and Beta Fusion, putative; PFAM: Transketolase domain protein; dehydrogenase E1 component; Transketolase central region.
   
 
 0.918
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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