STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB96192.1Nicotinate-nucleotide adenylyltransferase; InterPro IPR004820:IPR005248; COGs: COG1057 Nicotinic acid mononucleotide adenylyltransferase; KEGG: bha:BH1326 nicotinate-nucleotide adenylyltransferase; SPTR: Q11XI1 Probable nicotinate-nucleotide adenylyltransferase; PFAM: cytidylyltransferase; TIGRFAM: nicotinate (nicotinamide) nucleotide adenylyltransferase. (167 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.951
SMB84024.1
InterPro IPR002638:IPR004393; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; KEGG: hypothetical protein; K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating); SPTR: A1ZQF8 Nicotinate-nucleotide pyrophosphorylase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family.
    
 0.942
SMC00254.1
Competence/damage-inducible protein cinA; InterPro IPR001453:IPR008136:IPR008135; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; KEGG: dal:Dalk_4012 competence/damage-inducible protein CinA; SPTR: A1ZUS5 Competence-damage inducible protein; PFAM: CinA domain protein; molybdopterin binding domain; TIGRFAM: competence/damage-inducible protein CinA.
  
 
 0.918
SMB95209.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
 
 0.892
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.892
cobB
Silent information regulator protein Sir2; InterPro IPR003000; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; KEGG: hch:HCH_00109 Sir2 family NAD-dependent protein deacetylase; SPTR: A1ZZG3 NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily.
    
 0.889
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 0.887
SMB96630.1
Nicotinamide mononucleotide-binding domain; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: cvi:CV_1690 nicotinamide mononucleotide-binding domain; SPTR: A3HUY9 Nicotinamide-nucleotide adenylyltransferase, putative.
     
 0.822
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.787
SMB96055.1
Shikimate dehydrogenase; InterPro IPR013708:IPR006151; COGs: COG0169 Shikimate 5-dehydrogenase; KEGG: bha:BH1324 shikimate 5-dehydrogenase; SPTR: A4CQ38 Putative shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase.
 
  
 0.774
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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