node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMB83449.1 | SMB84593.1 | SAMN00120144_0701 | SAMN00120144_3402 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.842 |
SMB83449.1 | SMB87293.1 | SAMN00120144_0701 | SAMN00120144_1531 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | COGs: COG0035 Uracil phosphoribosyltransferase; KEGG: hypothetical protein; SPTR: A1ZSW6 Uracil phosphoribosyltransferase; PRIAM: Uracil phosphoribosyltransferase. | 0.884 |
SMB83449.1 | SMB87964.1 | SAMN00120144_0701 | SAMN00120144_1117 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | 1-phosphofructokinase; InterPro IPR011611:IPR001209:IPR002173:IPR017583; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); KEGG: gbm:Gbem_3234 1-phosphofructokinase; SPTR: A4LFV9 1-phosphofructokinase; PFAM: PfkB domain protein; TIGRFAM: 1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. | 0.903 |
SMB83449.1 | SMB88780.1 | SAMN00120144_0701 | SAMN00120144_3475 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Ribose-phosphate pyrophosphokinase; InterPro IPR000836:IPR000842:IPR005946; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; KEGG: cco:CCC13826_1015 ribose-phosphate pyrophosphokinase; SPTR: A3HZE2 Ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase. | 0.889 |
SMB83449.1 | SMB98140.1 | SAMN00120144_0701 | SAMN00120144_3499 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; InterPro IPR005841:IPR005844:IPR005846:IPR005845:IPR016066; COGs: COG1109 Phosphomannomutase; KEGG: baa:BA_0026 phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; SPTR: A1ZX67 Phosphomannomutase, putative; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II. | 0.859 |
SMB83449.1 | SMB98496.1 | SAMN00120144_0701 | SAMN00120144_3438 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Transketolase central region; InterPro IPR005476:IPR005475; COGs: COG3958 Transketolase C-terminal subunit; KEGG: pca:Pcar_2719 transketolase, C-terminal subunit; SPTR: A1ZKU9 Transketolase; PFAM: Transketolase central region; Transketolase domain protein. | 0.944 |
SMB83449.1 | SMB98500.1 | SAMN00120144_0701 | SAMN00120144_3440 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Transketolase domain protein; InterPro IPR005474; COGs: COG3959 Transketolase N-terminal subunit; KEGG: gbm:Gbem_0279 transketolase domain protein; SPTR: A1ZD78 Transketolase subunit A; PFAM: Transketolase domain protein. | 0.942 |
SMB83449.1 | SMB99820.1 | SAMN00120144_0701 | SAMN00120144_2782 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Ribulose-phosphate 3-epimerase; InterPro IPR000056; COGs: COG0036 Pentose-5-phosphate-3-epimerase; KEGG: glo:Glov_3613 ribulose-phosphate 3-epimerase; SPTR: A3HTG8 Ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase. | 0.977 |
SMB83449.1 | glyA | SAMN00120144_0701 | SAMN00120144_0699 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
SMB83449.1 | tal | SAMN00120144_0701 | SAMN00120144_1323 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. | 0.971 |
SMB84593.1 | SMB83449.1 | SAMN00120144_3402 | SAMN00120144_0701 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | 0.842 |
SMB84593.1 | SMB87964.1 | SAMN00120144_3402 | SAMN00120144_1117 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 1-phosphofructokinase; InterPro IPR011611:IPR001209:IPR002173:IPR017583; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); KEGG: gbm:Gbem_3234 1-phosphofructokinase; SPTR: A4LFV9 1-phosphofructokinase; PFAM: PfkB domain protein; TIGRFAM: 1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. | 0.626 |
SMB84593.1 | SMB88780.1 | SAMN00120144_3402 | SAMN00120144_3475 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Ribose-phosphate pyrophosphokinase; InterPro IPR000836:IPR000842:IPR005946; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; KEGG: cco:CCC13826_1015 ribose-phosphate pyrophosphokinase; SPTR: A3HZE2 Ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase. | 0.923 |
SMB84593.1 | SMB98140.1 | SAMN00120144_3402 | SAMN00120144_3499 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; InterPro IPR005841:IPR005844:IPR005846:IPR005845:IPR016066; COGs: COG1109 Phosphomannomutase; KEGG: baa:BA_0026 phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; SPTR: A1ZX67 Phosphomannomutase, putative; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II. | 0.871 |
SMB84593.1 | SMB98496.1 | SAMN00120144_3402 | SAMN00120144_3438 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Transketolase central region; InterPro IPR005476:IPR005475; COGs: COG3958 Transketolase C-terminal subunit; KEGG: pca:Pcar_2719 transketolase, C-terminal subunit; SPTR: A1ZKU9 Transketolase; PFAM: Transketolase central region; Transketolase domain protein. | 0.684 |
SMB84593.1 | SMB98500.1 | SAMN00120144_3402 | SAMN00120144_3440 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Transketolase domain protein; InterPro IPR005474; COGs: COG3959 Transketolase N-terminal subunit; KEGG: gbm:Gbem_0279 transketolase domain protein; SPTR: A1ZD78 Transketolase subunit A; PFAM: Transketolase domain protein. | 0.598 |
SMB84593.1 | SMB99820.1 | SAMN00120144_3402 | SAMN00120144_2782 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Ribulose-phosphate 3-epimerase; InterPro IPR000056; COGs: COG0036 Pentose-5-phosphate-3-epimerase; KEGG: glo:Glov_3613 ribulose-phosphate 3-epimerase; SPTR: A3HTG8 Ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase. | 0.978 |
SMB84593.1 | glyA | SAMN00120144_3402 | SAMN00120144_0699 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.401 |
SMB84593.1 | tal | SAMN00120144_3402 | SAMN00120144_1323 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. | 0.999 |
SMB87293.1 | SMB83449.1 | SAMN00120144_1531 | SAMN00120144_0701 | COGs: COG0035 Uracil phosphoribosyltransferase; KEGG: hypothetical protein; SPTR: A1ZSW6 Uracil phosphoribosyltransferase; PRIAM: Uracil phosphoribosyltransferase. | Sugar-phosphate isomerase, RpiB/LacA/LacB family; InterPro IPR003500:IPR004785; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; KEGG: nam:NAMH_1207 ribose 5-phosphate isomerase B; SPTR: A3HU34 Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. | 0.884 |