STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (301 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.997
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.951
SMB94813.1
Protein of unknown function DUF805; InterPro IPR008523; COGs: COG3152 membrane protein; KEGG: bvi:Bcep1808_0226 hypothetical protein; SPTR: P64590 Inner membrane protein yhaH; PFAM: protein of unknown function DUF805.
       0.773
SMB84412.1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
      0.729
SMC00255.1
Catalytic domain of components of various dehydrogenase complexes; InterPro IPR004167:IPR000089:IPR001078:IPR003016; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; KEGG: sus:Acid_0914 dihydrolipoyllysine-residue succinyltransferase; SPTR: A1ZHD0 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein.
 
  
 0.554
SMB94245.1
InterPro IPR002202; COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; KEGG: sus:Acid_5728 3-hydroxy-3-methylglutaryl-coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; PRIAM: Hydroxymethylglutaryl-CoA reductase (NADPH); SPTR: A1ZFK1 Hydroxymethylglutaryl-coenzyme A reductase.
 
      0.546
SMB97981.1
Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
  
 0.523
SMB94842.1
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
  
 0.506
SMB94806.1
Hypothetical protein; SPTR: A1ZYD3 Putative uncharacterized protein.
       0.491
SMB94773.1
Dehydrogenase E1 component; InterPro IPR005476:IPR001017:IPR005475; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; KEGG: jan:Jann_3081 dehydrogenase, E1 component; SPTR: A1ZLT5 2-oxoisovalerate dehydrogenase beta subunit; PFAM: dehydrogenase E1 component; Transketolase domain protein; Transketolase central region.
 
  
 0.463
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.