STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 0.992
SMB87028.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.877
SMB93651.1
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.877
SMB98386.1
Excinuclease ABC, A subunit; InterPro IPR003439:IPR017871:IPR004602; COGs: COG0178 Excinuclease ATPase subunit; KEGG: mxa:MXAN_3452 UvrABC system, A protein; SPTR: A3XG47 Excinuclease ABC, subunit A; PFAM: ABC transporter related; TIGRFAM: excinuclease ABC, A subunit.
 
 
 0.792
SMC00379.1
UvrD/REP helicase; InterPro IPR000212:IPR014016:IPR014017; COGs: COG0210 Superfamily I DNA and RNA helicase; KEGG: baa:BA_0876 UvrD/REP helicase; SPTR: A3HXJ5 ATP-dependent DNA helicase; PFAM: UvrD/REP helicase.
 
  
 0.666
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 
 0.575
SMB98566.1
DNA-(apurinic or apyrimidinic site) lyase; PRIAM: DNA-formamidopyrimidine glycosylase; InterPro IPR012319:IPR015886; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; KEGG: ATFPG-1/ATFPG-2/ATMMH-1/ATMMH-2/FPG-1/FPG-2 (FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 1, FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 2); DNA N-glycosylase; K10563 formamidopyrimidine-DNA glycosylase; SPTR: A1ZMR0 DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA-binding.
   
 
 0.546
SMB85694.1
Glycosyl transferase family 51; InterPro IPR001460:IPR001264; COGs: COG5009 Membrane carboxypeptidase/penicillin-binding protein; KEGG: dac:Daci_0887 peptidoglycan glycosyltransferase; SPTR: A3HXZ1 Penicillin-binding protein 1A; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase.
 
     0.536
SMC00474.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
  
 0.513
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.511
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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