STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
SMB84939.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1237 aa)    
Predicted Functional Partners:
SMB84902.1
5,10-methylenetetrahydrofolate reductase (NAD(P)); InterPro IPR003171; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; KEGG: hypothetical protein; SPTR: A1ZRW4 Methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H).
 
 
 0.999
SMB83924.1
Aspartate kinase; InterPro IPR001342:IPR002912:IPR005106:IPR001048:IPR001341; COGs: COG0527 Aspartokinase; KEGG: xcc:XCC1800 bifunctional aspartokinase I/homeserine dehydrogenase I; SPTR: A4CK37 Aspartokinase/homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; TIGRFAM: aspartate kinase.
  
 
 0.967
SMB96841.1
Cystathionine gamma-lyase; InterPro IPR001597:IPR000277; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; KEGG: ade:Adeh_3707 cystathionine gamma-lyase; SPTR: A3HW94 Cys/Met metabolism PLP-dependent enzyme superfamily protein; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Cystathionine gamma-lyase.
  
 
 0.955
SMB95843.1
O-acetylhomoserine sulfhydrylase; InterPro IPR000653:IPR000277:IPR006235; COGs: COG2873 O-acetylhomoserine sulfhydrylase; KEGG: afw:Anae109_0967 O-acetylhomoserine/O-acetylserine sulfhydrylase; SPTR: A3HST4 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; PRIAM: O-acetylhomoserine aminocarboxypropyltransferase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase.
  
 
 0.953
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.953
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.953
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.915
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
 0.901
SMB89339.1
Cysteine synthase; InterPro IPR001926:IPR001216:IPR010916:IPR005856:IPR005859; COGs: COG0031 Cysteine synthase; KEGG: mxa:MXAN_1571 cysteine synthase A; SPTR: A5P7E9 Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: cysteine synthase; cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.899
SMB88276.1
Cystathionine beta-synthase; InterPro IPR001926:IPR001216; COGs: COG0031 Cysteine synthase; KEGG: AGAP012897-PA; SPTR: A1ZHL6 Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
    
 0.899
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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