STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB99930.1DNA polymerase III, epsilon subunit; InterPro IPR000305:IPR013520:IPR006055:IPR006054; COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); KEGG: dar:Daro_1907 DNA polymerase III, epsilon subunit; SPTR: A1ZC44 DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; PRIAM: DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, epsilon subunit. (493 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.964
SMC00474.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.908
SMB96905.1
DNA polymerase III, alpha subunit; InterPro IPR011708:IPR004013:IPR003141:IPR004805; COGs: COG0587 DNA polymerase III alpha subunit; KEGG: gsu:GSU1401 DNA polymerase III, alpha subunit; SPTR: A1ZEC3 DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein; PFAM: DNA polymerase III alpha subunit; PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit.
    
 0.902
SMB99860.1
DNA polymerase III, delta subunit; InterPro IPR010372:IPR005790; COGs: COG1466 DNA polymerase III delta subunit; KEGG: bar:GBAA4548 DNA polymerase III subunit delta; SPTR: A1ZQ74 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.901
SMB96730.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: sfu:Sfum_0156 DNA polymerase III, delta prime subunit; SPTR: A1ZNC9 Putative DNA polymerase III, delta subunit.
  
 0.898
SMC00572.1
InterPro IPR013520:IPR006055; COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; KEGG: hypothetical protein; SPTR: A4AN35 DNA polymerase III alpha subunit; SMART: Exonuclease; PFAM: Exonuclease RNase T and DNA polymerase III.
    
 0.867
SMC00379.1
UvrD/REP helicase; InterPro IPR000212:IPR014016:IPR014017; COGs: COG0210 Superfamily I DNA and RNA helicase; KEGG: baa:BA_0876 UvrD/REP helicase; SPTR: A3HXJ5 ATP-dependent DNA helicase; PFAM: UvrD/REP helicase.
 
 
 0.856
SMB92092.1
KEGG: sde:Sde_3865 hypothetical protein.
  
 
 0.766
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
 
 0.766
SMB88080.1
DNA polymerase-3 subunit gamma/tau; KEGG: hypothetical protein; SPTR: A3HWY7 Putative uncharacterized protein.
  
 0.760
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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