STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB88804.1Cystathionine gamma-lyase; InterPro IPR001597:IPR000277; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; KEGG: bha:BH0542 cystathionine gamma-synthase; SPTR: A1HQW4 Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Cystathionine gamma-lyase. (375 aa)    
Predicted Functional Partners:
SMB84939.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.896
SMB88276.1
Cystathionine beta-synthase; InterPro IPR001926:IPR001216; COGs: COG0031 Cysteine synthase; KEGG: AGAP012897-PA; SPTR: A1ZHL6 Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
 0.856
SMB83924.1
Aspartate kinase; InterPro IPR001342:IPR002912:IPR005106:IPR001048:IPR001341; COGs: COG0527 Aspartokinase; KEGG: xcc:XCC1800 bifunctional aspartokinase I/homeserine dehydrogenase I; SPTR: A4CK37 Aspartokinase/homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; PRIAM: Aspartate kinase., Homoserine dehydrogenase; TIGRFAM: aspartate kinase.
 
 
 0.850
SMB84902.1
5,10-methylenetetrahydrofolate reductase (NAD(P)); InterPro IPR003171; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; KEGG: hypothetical protein; SPTR: A1ZRW4 Methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H).
  
 0.816
SMB89339.1
Cysteine synthase; InterPro IPR001926:IPR001216:IPR010916:IPR005856:IPR005859; COGs: COG0031 Cysteine synthase; KEGG: mxa:MXAN_1571 cysteine synthase A; SPTR: A5P7E9 Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: cysteine synthase; cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.789
SMC00533.1
Transketolase domain protein; InterPro IPR005476:IPR001017:IPR005475; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; KEGG: hypothetical protein; SPTR: A1ZGW0 (Pyruvate) Oxoisovalerate Dehydrogenase Alpha and Beta Fusion, putative; PFAM: Transketolase domain protein; dehydrogenase E1 component; Transketolase central region.
    
 0.782
SMC00725.1
Plasmid recombination protein; InterPro IPR001668; KEGG: dds:Ddes_0434 plasmid recombination protein; SPTR: P15255 65 kDa protein; PFAM: plasmid recombination protein.
  
 0.742
SMB90393.1
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 0.731
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.702
SMB97417.1
Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor; InterPro IPR001450; COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; KEGG: mxa:MXAN_5557 putative iron-sulfur binding oxidoreductase; SPTR: A1ZL71 Molybdopterin oxidoreductase, iron-sulfur binding subunit.
     
 0.675
Your Current Organism:
Hymenobacter roseosalivarius
NCBI taxonomy Id: 645990
Other names: H. roseosalivarius DSM 11622, Hymenobacter roseosalivarius AA-718, Hymenobacter roseosalivarius DSM 11622, Hymenobacter roseosalivarius str. DSM 11622, Hymenobacter roseosalivarius strain DSM 11622
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