STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_0315KEGG: bvi:Bcep1808_1157 hypothetical protein; SPTR: Putative uncharacterized protein. (325 aa)    
Predicted Functional Partners:
addA
ATP-dependent helicase/nuclease subunit A; ATP-dependent DNA helicase.
  
 
 0.836
Sgly_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.782
Sgly_0316
COGs: COG3773 Cell wall hydrolyses involved in spore germination; InterPro IPR011105; KEGG: hor:Hore_03060 spore cortex-lytic enzyme SleB; PFAM: Cell wall hydrolase, SleB; SPTR: Spore cortex-lytic enzyme SleB; PFAM: Cell Wall Hydrolase.
       0.773
Sgly_2917
ATP-dependent DNA helicase, RecQ-like protein; COGs: COG0514 Superfamily II DNA helicase; InterPro IPR011545: IPR001650: IPR018982: IPR002121: IPR 014001: IPR006293: IPR018329; KEGG: dhd:Dhaf_2928 ATP-dependent DNA helicase RecQ; PFAM: RQC domain; DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase/RNase D C-terminal, HRDC domain; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; Helicase/RNase D C-terminal, HRDC domain; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase [...]
  
 
 0.750
Sgly_0314
KEGG: mno:Mnod_3582 type I restriction-modification system methyltransferase subunit-like protein; SPTR: Type I restriction-modification system methyltransferase subunit-like protein; PFAM: Methyltransferase small domain; Belongs to the methyltransferase superfamily.
  
    0.671
topB
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
   
 
 0.633
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.633
Sgly_1489
Iron (metal) dependent repressor, DtxR family; COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR000835: IPR001367; KEGG: adg:Adeg_0633 iron (metal) dependent repressor, DtxR family; PFAM: HTH transcriptional regulator, MarR; SMART: Iron dependent repressor; HTH transcriptional regulator, MarR; SPTR: Predicted protein; PFAM: Iron dependent repressor, N-terminal DNA binding domain.
  
     0.622
Sgly_0087
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: smb:smi_1319 hypothetical protein; PFAM: DNA helicase, UvrD/REP type; SPTR: Putative uncharacterized protein; PFAM: UvrD/REP helicase.
  
 
 0.613
Sgly_0719
COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212: IPR005751; KEGG: dsy:DSY3891 hypothetical protein; PFAM: DNA helicase, UvrD/REP type; SPTR: Putative uncharacterized protein; TIGRFAM: DNA helicase, ATP-dependent, PcrA type; PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA.
  
 
 0.613
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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