node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sgly_0706 | Sgly_0707 | Sgly_0706 | Sgly_0707 | KEGG: dhd:Dhaf_0975 hypothetical protein; SPTR: Putative uncharacterized protein. | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | 0.465 |
Sgly_0707 | Sgly_0706 | Sgly_0707 | Sgly_0706 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | KEGG: dhd:Dhaf_0975 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.465 |
Sgly_0707 | hisA | Sgly_0707 | Sgly_0715 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | 0.417 |
Sgly_0707 | hisB | Sgly_0707 | Sgly_0713 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: dhd:Dhaf_1494 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.442 |
Sgly_0707 | hisD | Sgly_0707 | Sgly_0711 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.446 |
Sgly_0707 | hisF | Sgly_0707 | Sgly_0716 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.409 |
Sgly_0707 | hisG | Sgly_0707 | Sgly_0710 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.424 |
Sgly_0707 | hisH | Sgly_0707 | Sgly_0714 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.408 |
Sgly_0707 | hisI | Sgly_0707 | Sgly_0717 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | Phosphoribosyl-ATP pyrophosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein hisIE; InterPro IPR002496: IPR021130: IPR008179; KEGG: dhd:Dhaf_1498 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP diphosphatase; SPTR: Putative uncharacterized protein; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribo [...] | 0.556 |
Sgly_0707 | hisZ | Sgly_0707 | Sgly_0708 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.616 |
Sgly_0707 | pfkA | Sgly_0707 | Sgly_0709 | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. | 0.463 |
hisA | Sgly_0707 | Sgly_0715 | Sgly_0707 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | 0.417 |
hisA | hisB | Sgly_0715 | Sgly_0713 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: dhd:Dhaf_1494 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisD | Sgly_0715 | Sgly_0711 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisF | Sgly_0715 | Sgly_0716 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Sgly_0715 | Sgly_0710 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.997 |
hisA | hisH | Sgly_0715 | Sgly_0714 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Sgly_0715 | Sgly_0717 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | Phosphoribosyl-ATP pyrophosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein hisIE; InterPro IPR002496: IPR021130: IPR008179; KEGG: dhd:Dhaf_1498 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP diphosphatase; SPTR: Putative uncharacterized protein; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribo [...] | 0.999 |
hisA | hisZ | Sgly_0715 | Sgly_0708 | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062: IPR006063; KEGG: dhd:Dhaf_1496 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide i [...] | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.958 |
hisB | Sgly_0707 | Sgly_0713 | Sgly_0707 | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: dhd:Dhaf_1494 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | TrpR like protein, YerC/YecD; COGs: COG4496 conserved hypothetical protein; InterPro IPR000831: IPR013368; KEGG: dhd:Dhaf_1488 TrpR like protein, YerC/YecD; PFAM: Trp repressor; SPTR: Putative uncharacterized protein; TIGRFAM: TrpR homologue YerC/YecD; PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. | 0.442 |