STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_1389CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (164 aa)    
Predicted Functional Partners:
cas2-2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 
 0.990
cas1-2
CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 
 0.981
Sgly_1388
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR006483: IPR006474: IPR014001; KEGG: dae:Dtox_0917 CRISPR-associated helicase Cas3; SMART: DEAD-like helicase, N-terminal; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: Helicase Cas3, CRISPR-associated, core; CRISPR-associated HD domain; PFAM: HD domain; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.
 
  
 0.936
Sgly_1386
CRISPR-associated autoregulator, Cst2 family; COGs: COG1857 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR010154: IPR013414; KEGG: dae:Dtox_0915 CRISPR-associated autoregulator, DevR family; SPTR: CRISPR-associated autoregulator, DevR family; TIGRFAM: CRISPR-associated regulatory DevR; CRISPR-associated negative autoregulator; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated regulatory protein, DevR family.
 
   
 0.903
Sgly_1387
CRISPR-associated protein, Cas5t family; InterPro IPR013337: IPR013422; KEGG: dae:Dtox_0916 CRISPR-associated protein Cas5; SPTR: CRISPR-associated protein Cas5; TIGRFAM: CRISPR-associated protein Cas5, N-terminal domain; CRISPR-associated protein Cas5, Tneap type; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, Tneap subtype; CRISPR-associated protein Cas5, N-terminal domain.
 
   
 0.903
Sgly_1384
CRISPR-associated protein Cas6; COGs: COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR002743: IPR010156; KEGG: dae:Dtox_0913 CRISPR-associated protein Cas6; PFAM: Protein of unknown function DUF57; SPTR: CRISPR-associated protein Cas6; TIGRFAM: CRISPR-associated protein, Cas6; PFAM: CRISPR associated protein Cas6; TIGRFAM: CRISPR-associated endoribonuclease Cas6.
 
   
 0.901
Sgly_1385
InterPro IPR019121: IPR010180; KEGG: dae:Dtox_0914 CRISPR-associated CXXC_CXXC protein Cst1; PFAM: CRISPR-associated protein, CXXC-CXXC region; SPTR: CRISPR-associated CXXC_CXXC protein Cst1; TIGRFAM: CRISPR-associated protein, CXXC-CXXC; PFAM: CRISPR-associated protein (Cas_CXXC_CXXC); TIGRFAM: CRISPR-associated CXXC_CXXC protein Cst1.
 
   
 0.900
cas2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
   
 
 0.821
cas1
CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
   
 
 0.698
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.