node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sgly_1798 | Sgly_1799 | Sgly_1798 | Sgly_1799 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dsy:DSY1663 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase alpha chain; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | 0.999 |
Sgly_1798 | Sgly_2016 | Sgly_1798 | Sgly_2016 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | 0.727 |
Sgly_1798 | Sgly_2247 | Sgly_1798 | Sgly_2247 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR004821: IPR002606; KEGG: dhd:Dhaf_3672 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: FAD synthase; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.814 |
Sgly_1798 | Sgly_2341 | Sgly_1798 | Sgly_2341 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.742 |
Sgly_1798 | metK | Sgly_1798 | Sgly_0695 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.595 |
Sgly_1798 | nusB | Sgly_1798 | Sgly_1905 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.660 |
Sgly_1798 | ribBA | Sgly_1798 | Sgly_1800 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
Sgly_1798 | ribH | Sgly_1798 | Sgly_1801 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
Sgly_1799 | Sgly_1798 | Sgly_1799 | Sgly_1798 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dsy:DSY1663 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase alpha chain; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
Sgly_1799 | Sgly_2247 | Sgly_1799 | Sgly_2247 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dsy:DSY1663 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase alpha chain; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR004821: IPR002606; KEGG: dhd:Dhaf_3672 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: FAD synthase; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.942 |
Sgly_1799 | ribBA | Sgly_1799 | Sgly_1800 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dsy:DSY1663 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase alpha chain; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
Sgly_1799 | ribH | Sgly_1799 | Sgly_1801 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dsy:DSY1663 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Riboflavin synthase alpha chain; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
Sgly_2016 | Sgly_1798 | Sgly_2016 | Sgly_1798 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.727 |
Sgly_2016 | Sgly_2247 | Sgly_2016 | Sgly_2247 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR004821: IPR002606; KEGG: dhd:Dhaf_3672 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: FAD synthase; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.613 |
Sgly_2016 | Sgly_2341 | Sgly_2016 | Sgly_2341 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.555 |
Sgly_2016 | metK | Sgly_2016 | Sgly_0695 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.410 |
Sgly_2016 | pyrB | Sgly_2016 | Sgly_0675 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR006132: IPR006131: IPR002082; KEGG: dhd:Dhaf_4019 aspartate carbamoyltransferase catalytic subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltransferase; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbam [...] | 0.627 |
Sgly_2016 | ribBA | Sgly_2016 | Sgly_1800 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.927 |
Sgly_2016 | ribH | Sgly_2016 | Sgly_1801 | COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.912 |
Sgly_2247 | Sgly_1798 | Sgly_2247 | Sgly_1798 | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR004821: IPR002606; KEGG: dhd:Dhaf_3672 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: FAD synthase; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.814 |