STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (725 aa)    
Predicted Functional Partners:
Sgly_3351
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
 
 0.986
Sgly_2917
ATP-dependent DNA helicase, RecQ-like protein; COGs: COG0514 Superfamily II DNA helicase; InterPro IPR011545: IPR001650: IPR018982: IPR002121: IPR 014001: IPR006293: IPR018329; KEGG: dhd:Dhaf_2928 ATP-dependent DNA helicase RecQ; PFAM: RQC domain; DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase/RNase D C-terminal, HRDC domain; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; Helicase/RNase D C-terminal, HRDC domain; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: DNA helicase, ATP-dependent, RecQ type, bacterial; DNA helicase [...]
 
 0.981
Sgly_2702
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583: IPR006982: IPR002932: IPR002489; KEGG: dae:Dtox_3758 glutamate synthase (ferredoxin); PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
  
  
 0.971
Sgly_0165
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR019752: IPR019456: IPR011766: IPR 011895; KEGG: dhd:Dhaf_0054 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SPTR: Pyruvate-flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavo [...]
  
   0.916
leuS
COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR002300: IPR013155: IPR002302; KEGG: dhd:Dhaf_4328 leucyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ia; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; PRIAM: Valine--tRNA ligase., Leucine--tRNA ligase; SPTR: Leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family.
   
 
 0.902
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.844
Sgly_1057
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006054: IPR006055: IPR013520: IPR001357; KEGG: sna:Snas_2943 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; BRCT; SMART: Exonuclease; SPTR: Exonuclease RNase T and DNA polymerase III; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
   
 
 0.828
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.778
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.777
trmFO
Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
  
    0.750
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.