STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_2053Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR004392: IPR003495; KEGG: cpy:Cphy_1737 hydrogenase accessory protein HypB; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; SPTR: Hydrogenase accessory protein HypB; TIGRFAM: Hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB. (216 aa)    
Predicted Functional Partners:
hypA
Hydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.985
Sgly_2051
Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: cth:Cthe_3014 hydrogenase formation HypD protein; PFAM: Hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: Hydrogenase formation HypD protein; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD.
 
  
 0.961
ureF
Urease accessory protein ureF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
 
 0.946
Sgly_2050
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR011854: IPR000728: IPR010918; KEGG: cpy:Cphy_1741 hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein; SPTR: Hydrogenase expression/formation protein HypE; TIGRFAM: Hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
  
 0.909
Sgly_2052
InterPro IPR001109; KEGG: cth:Cthe_3015 hydrogenase assembly chaperone HypC/HupF; PFAM: Hydrogenase expression/formation protein, HupF/HypC; SPTR: Hydrogenase assembly chaperone hypC/hupF; TIGRFAM: Hydrogenase expression/formation protein, HupF/HypC; PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
  
 0.899
ureE
Urease accessory protein ureE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
  
 
 0.894
Sgly_2056
COGs: COG3261 Ni Fe-hydrogenase III large subunit; InterPro IPR001501: IPR001135; KEGG: cpy:Cphy_1734 NADH-ubiquinone oxidoreductase chain 49kDa; PFAM: NADH-quinone oxidoreductase, subunit D; Nickel-dependent hydrogenase, large subunit; PRIAM: NADH dehydrogenase (quinone); SPTR: NADH-ubiquinone oxidoreductase chain 49kDa; PFAM: Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Nickel-dependent hydrogenase.
   
 
 0.878
Sgly_2124
(NiFe) hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterPro IPR004421: IPR001792: IPR011125: IPR006070; KEGG: dhd:Dhaf_3636 (NiFe) hydrogenase maturation protein HypF; PFAM: Sua5/YciO/YrdC, N-terminal; Acylphosphatase-like; Zinc finger, HypF-type; SPTR: Hydrogenase maturation protein hypF; TIGRFAM: Hydrogenase maturation factor, HypF-type; PFAM: HypF finger; yrdC domain; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF.
 
   
 0.868
ureD
Urease accessory protein ureD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
 
 0.839
Sgly_2055
Hypothetical protein; COGs: COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); KEGG: mpi:Mpet_0464 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding.
     
 0.785
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.