node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sgly_0460 | Sgly_2263 | Sgly_0460 | Sgly_2263 | Di-trans,poly-cis-decaprenylcistransferase; COGs: COG0020 Undecaprenyl pyrophosphate synthase; InterPro IPR001441; KEGG: clj:CLJU_c35470 undecaprenyl pyrophosphate synthase; PFAM:Di-trans-poly-cis-decaprenylcistransferase-lik e; PRIAM: Di-trans,poly-cis-decaprenylcistransferase; SPTR: Undecaprenyl pyrophosphate synthase; PFAM: Putative undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase. | Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.919 |
Sgly_0460 | trmFO | Sgly_0460 | Sgly_2274 | Di-trans,poly-cis-decaprenylcistransferase; COGs: COG0020 Undecaprenyl pyrophosphate synthase; InterPro IPR001441; KEGG: clj:CLJU_c35470 undecaprenyl pyrophosphate synthase; PFAM:Di-trans-poly-cis-decaprenylcistransferase-lik e; PRIAM: Di-trans,poly-cis-decaprenylcistransferase; SPTR: Undecaprenyl pyrophosphate synthase; PFAM: Putative undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase. | Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.582 |
Sgly_2263 | Sgly_0460 | Sgly_2263 | Sgly_0460 | Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | Di-trans,poly-cis-decaprenylcistransferase; COGs: COG0020 Undecaprenyl pyrophosphate synthase; InterPro IPR001441; KEGG: clj:CLJU_c35470 undecaprenyl pyrophosphate synthase; PFAM:Di-trans-poly-cis-decaprenylcistransferase-lik e; PRIAM: Di-trans,poly-cis-decaprenylcistransferase; SPTR: Undecaprenyl pyrophosphate synthase; PFAM: Putative undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase. | 0.919 |
Sgly_2263 | trmFO | Sgly_2263 | Sgly_2274 | Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.640 |
Sgly_2276 | codY | Sgly_2276 | Sgly_2270 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.409 |
Sgly_2276 | hslU | Sgly_2276 | Sgly_2271 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | ATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.529 |
Sgly_2276 | hslV | Sgly_2276 | Sgly_2272 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | ATP dependent peptidase CodWX, CodW component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.604 |
Sgly_2276 | topA | Sgly_2276 | Sgly_2275 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.953 |
Sgly_2276 | topB | Sgly_2276 | Sgly_2022 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.456 |
Sgly_2276 | trmFO | Sgly_2276 | Sgly_2274 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.714 |
Sgly_2276 | xerC-2 | Sgly_2276 | Sgly_2273 | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | Tyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.707 |
codY | Sgly_2276 | Sgly_2270 | Sgly_2276 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | 0.409 |
codY | hslU | Sgly_2270 | Sgly_2271 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | ATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.931 |
codY | hslV | Sgly_2270 | Sgly_2272 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | ATP dependent peptidase CodWX, CodW component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.756 |
codY | topA | Sgly_2270 | Sgly_2275 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.691 |
codY | topB | Sgly_2270 | Sgly_2022 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.564 |
codY | trmFO | Sgly_2270 | Sgly_2274 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.562 |
codY | xerC-2 | Sgly_2270 | Sgly_2273 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Tyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.411 |
hslU | Sgly_2276 | Sgly_2271 | Sgly_2276 | ATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: dhd:Dhaf_3718 DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: Putative uncharacterized protein; TIGRFAM: DNA recombination-mediator protein A; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. | 0.529 |
hslU | codY | Sgly_2271 | Sgly_2270 | ATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.931 |