STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Sgly_2571Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)    
Predicted Functional Partners:
rph
RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
 
    0.990
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.976
Sgly_2016
COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR000644: IPR001093; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; PRIAM: IMP dehydrogenase; SPTR: IMP dehydrogenase/GMP reductase; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase.
  
 0.942
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    0.934
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.931
Sgly_2670
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR005904; KEGG: dhd:Dhaf_1437 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: Hypoxanthine phosphoribosyl transferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 
 0.906
Sgly_2929
COGs: COG0518 GMP synthase - Glutamine amidotransferase domain; InterPro IPR000991; KEGG: ccb:Clocel_3264 glutamine amidotransferase class-I; PFAM: Glutamine amidotransferase class-I, C-terminal; SPTR: Glutamine amidotransferase class-I; PFAM: Glutamine amidotransferase class-I.
  
 
 0.905
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.900
Sgly_2080
Protein of unknown function DUF2179; COGs: COG1284 conserved hypothetical protein; InterPro IPR003740: IPR019264; KEGG: dhd:Dhaf_3014 protein of unknown function DUF161; PFAM: Protein of unknown function DUF2179; Protein of unknown function DUF161; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized BCR, YitT family COG1284; Uncharacterized protein conserved in bacteria (DUF2179).
 
    0.894
Sgly_1956
Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979: IPR004843; KEGG: dsy:DSY1878 hypothetical protein; PFAM: Metallophosphoesterase; SPTR: Putative uncharacterized protein; TIGRFAM: Phosphodiesterase MJ0936; TIGRFAM: phosphoesterase, MJ0936 family.
  
  
 0.867
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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