STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_2716Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722; KEGG: slp:Slip_0120 biotin and thiamin synthesis associated; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SPTR: Biotin and thiamin synthesis associated; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (487 aa)    
Predicted Functional Partners:
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.986
Sgly_2718
Iron-only hydrogenase maturation protein HydF; COGs: COG1160 GTPase; InterPro IPR002917: IPR005225; KEGG: pth:PTH_0982 GTPase; PFAM: GTP-binding protein, HSR1-related; SPTR: Predicted GTPase; TIGRFAM: Small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
   
 0.972
Sgly_1654
Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR012726: IPR007197: IPR010722; KEGG: dae:Dtox_1681 thiazole biosynthesis protein ThiH; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SPTR: Thiazole biosynthesis protein ThiH; TIGRFAM: Thiazole biosynthesis ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH.
  
  
 
0.916
Sgly_2715
KEGG: cdl:CDR20291_2059 hypothetical protein; SPTR: Putative uncharacterized protein.
 
   
 0.894
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.810
Sgly_2914
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001041: IPR019574: IPR004108: IPR003149: IPR 013352; KEGG: cce:Ccel_2467 hydrogenase, Fe-only; PFAM: Iron hydrogenase, large subunit, C-terminal; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; Ferredoxin; Iron hydrogenase, small subunit-like; SPTR: Hydrogenase, Fe-only; TIGRFAM: Iron hydrogenase, subset; PFAM: Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron h [...]
 
   
 0.750
Sgly_2188
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR006311: IPR013352: IPR004108: IPR003149; KEGG: dsy:DSY4712 putative hydrogenase large subunit; PFAM: Iron hydrogenase, large subunit, C-terminal; Iron hydrogenase, small subunit-like; PRIAM: Ferredoxin hydrogenase; SPTR: Putative hydrogenase large subunit; TIGRFAM: Iron hydrogenase, subset; Twin-arginine translocation pathway, signal sequence; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Iron hydrogenase small subunit; TIGRFAM: hydrogenases, Fe-only.
 
     0.736
Sgly_2185
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR006311: IPR013352: IPR004108: IPR003149; KEGG: dhd:Dhaf_4621 hydrogenase, Fe-only; PFAM: Iron hydrogenase, large subunit, C-terminal; Iron hydrogenase, small subunit-like; PRIAM: Ferredoxin hydrogenase; SPTR: Hydrogenase, Fe-only; TIGRFAM: Iron hydrogenase, subset; Twin-arginine translocation pathway, signal sequence; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Iron hydrogenase small subunit; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; hydroge [...]
 
     0.735
Sgly_2230
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660: IPR003661: IPR003594: IPR001789: IPR 008207; KEGG: cth:Cthe_1825 Hpt sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, phosphotransfer (Hpt) domain; SMART: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, d [...]
  
  
 0.716
Sgly_0622
Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
    0.692
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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