STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_2725Anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197: IPR012840; KEGG: bpb:bpr_III031 anaerobic ribonucleoside triphosphate reductase activating protein NrdG2; PFAM: Radical SAM; SPTR: Putative uncharacterized protein; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein. (222 aa)    
Predicted Functional Partners:
Sgly_2726
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144: IPR012833; KEGG: thx:Thet_1768 anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
  
 0.995
Sgly_2728
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: afl:Aflv_2814 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; PRIAM: Acetaldehyde dehydrogenase (acetylating); SPTR: Iron-containing alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
  
 0.723
nrdR
Transcriptional repressor nrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
       0.669
Sgly_2390
COGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184: IPR001150: IPR005949; KEGG: hor:Hore_23170 formate acetyltransferase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: Formate acetyltransferase; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1.
 
  
 0.616
Sgly_0165
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR019752: IPR019456: IPR011766: IPR 011895; KEGG: dhd:Dhaf_0054 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SPTR: Pyruvate-flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavo [...]
     
 0.594
Sgly_2533
Pyruvate formate-lyase PFL; COGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184: IPR001150; KEGG: ddf:DEFDS_2103 pyruvate formate-lyase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; SPTR: Pyruvate formate-lyase; PFAM: Glycine radical; Pyruvate formate lyase.
  
  
 0.408
Sgly_2536
4-hydroxyphenylacetate decarboxylase subunit B; COGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184: IPR001150; KEGG: cbk:CLL_A1723 4-hydroxyphenylacetate decarboxylase, catalytic subunit; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical; SPTR: 4-hydroxyphenylacetate decarboxylase, catalytic subunit; PFAM: Glycine radical; Pyruvate formate lyase.
  
  
 0.408
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.