STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sgly_2935Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR013655: IPR000160: IPR001633: IPR001610: IPR 000014; KEGG: tte:TTE1081 diguanylate cyclase/phosphodiesterase; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold-3; PRIAM: Diguanylate kinase; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAC motif; SPTR: PAS fold family protein; TIGRFAM: Diguanylate cyclase, predicted; PAS; PFAM: EAL domain; GGDE [...] (723 aa)    
Predicted Functional Partners:
Sgly_2231
COGs: COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase); InterPro IPR001789: IPR003661: IPR003594; KEGG: cth:Cthe_1826 response regulator receiver sensor signal transduction histidine kinase; PFAM: Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; ATPase-like, ATP-binding domain; SMART: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; SPTR: Response regulator receiver sensor signal transduction histidine kinase; PFAM: Hi [...]
  
 0.957
Sgly_1176
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: cth:Cthe_0808 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase, CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase, CheR-type; SPTR: MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
 
      0.873
Sgly_2652
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: dhd:Dhaf_4203 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase, CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase, CheR-type; SPTR: MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
 
      0.865
Sgly_2709
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR000014: IPR001610: IPR000160: IPR001633: IPR 013767; KEGG: tjr:TherJR_0997 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAC motif; PAS; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: Diguanylate cyclase [...]
 
 
0.862
Sgly_1383
NMT1/THI5-like protein; COGs: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components; KEGG: cbe:Cbei_1941 NMT1/THI5-like protein; SPTR: NMT1/THI5-like protein; PFAM: NMT1/THI5 like.
 
      0.845
Sgly_1728
Diguanylate cyclase and metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR000014: IPR000160: IPR013767: IPR006674: IPR 003607; KEGG: swo:Swol_1469 HD-GYP domain-containing protein; PFAM: Diguanylate cyclase, predicted; PAS fold; Metal-dependent phosphohydrolase, HD subdomain; SMART: Diguanylate cyclase, predicted; Metal-dependent phosphohydrolase, HD domain; SPTR: Diguanylate cyclase with PAS/PAC and GAF sensors; TIGRFAM: Diguanylate cyclase, predicted; PAS; PFAM: HD domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain.
 
 
0.841
Sgly_1627
Diguanylate cyclase and metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR000014: IPR000160: IPR006675: IPR013655: IPR 006674: IPR001610: IPR003607; KEGG: cbb:CLD_3030 putative sensory box-containing diguanylate cyclase; PFAM: Diguanylate cyclase, predicted; PAS fold-3; Metal-dependent phosphohydrolase, HD subdomain; SMART: Diguanylate cyclase, predicted; PAC motif; Metal-dependent phosphohydrolase, HD domain; SPTR: Putative sensory box-containing diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted; PAS; HDIG; PFAM: HD domain; GGDEF domain; PAS fold; T [...]
 
 
0.839
Sgly_2175
Ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905; KEGG: tjr:TherJR_0702 ammonium transporter; PFAM: Ammonium transporter; SPTR: Ammonium transporter; TIGRFAM: Ammonium transporter; PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter; (TC 1.A.11.
 
      0.838
Sgly_2710
Ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905; KEGG: drm:Dred_2862 ammonium transporter; PFAM: Ammonium transporter; SPTR: Ammonium transporter; TIGRFAM: Ammonium transporter; PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter; (TC 1.A.11.
 
      0.836
Sgly_2230
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660: IPR003661: IPR003594: IPR001789: IPR 008207; KEGG: cth:Cthe_1825 Hpt sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, phosphotransfer (Hpt) domain; SMART: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, d [...]
  
 0.835
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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