STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Sgly_3313Alcohol dehydrogenase (NADP(+)); COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154: IPR013149; KEGG: abu:Abu_1042 NADP-dependent alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, zinc-binding; Alcohol dehydrogenase GroES-like; PRIAM: Alcohol dehydrogenase (NADP(+)); SPTR: Alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (353 aa)    
Predicted Functional Partners:
Sgly_0165
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR019752: IPR019456: IPR011766: IPR 011895; KEGG: dhd:Dhaf_0054 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate dehydrogenase (NADP(+)); SPTR: Pyruvate-flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavo [...]
  
  
 0.699
Sgly_2728
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: afl:Aflv_2814 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; PRIAM: Acetaldehyde dehydrogenase (acetylating); SPTR: Iron-containing alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.611
Sgly_1200
HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR006402: IPR006439: IPR005834: IPR013118; KEGG: ckr:CKR_1932 hypothetical protein; PFAM: Haloacid dehalogenase-like hydrolase; Mannitol dehydrogenase, C-terminal; SPTR: Putative uncharacterized protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Mannitol dehydrogenase C-terminal domain; haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third mot [...]
  
  
 0.590
Sgly_1406
Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide.
  
 
 0.543
Sgly_3315
Transcriptional regulator, GntR family; COGs: COG2188 Transcriptional regulators; InterPro IPR000524: IPR011663; KEGG: gct:GC56T3_1227 transcriptional regulator, GntR family; PFAM: UbiC transcription regulator-associated; HTH transcriptional regulator, GntR; SMART: HTH transcriptional regulator, GntR; SPTR: Transcriptional regulator, GntR family; PFAM: Bacterial regulatory proteins, gntR family; UTRA domain.
 
   
 0.496
Sgly_1580
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076: IPR017941; KEGG: cth:Cthe_1461 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; Rieske [2Fe-2S] iron-sulphur domain; SPTR: FAD dependent oxidoreductase; PFAM: Rieske [2Fe-2S] domain; FAD dependent oxidoreductase.
  
  
 0.486
Sgly_1206
2,4-dienoyl-CoA reductase (NADPH); COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155: IPR013027; KEGG: tte:TTE2131 NADH:flavin oxidoreductase; PFAM: NADH:flavin oxidoreductase/NADH oxidase, N-terminal; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: 2,4-dienoyl-CoA reductase (NADPH); SPTR: NADH:flavin oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family.
  
  
 0.483
Sgly_1736
CoA-disulfide reductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR013027: IPR004099: IPR001763; KEGG: ttm:Tthe_0249 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Rhodanese-like; PRIAM: CoA-disulfide reductase; SMART: Rhodanese-like; SPTR: Putative uncharacterized protein; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Rhodanese-like domain.
  
  
 0.458
deoC-2
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
  
    0.446
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.437
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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