STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
Sgly_3333Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR001789: IPR000792; KEGG: amt:Amet_4202 two component LuxR family transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SMART: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulato [...] (208 aa)    
Predicted Functional Partners:
Sgly_3334
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR011712: IPR003594; KEGG: amt:Amet_4203 integral membrane sensor signal transduction histidine kinase; PFAM: Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain; ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: Integral membrane sensor signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 0.978
Sgly_2781
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR011712: IPR003594; KEGG: gym:GYMC10_3654 integral membrane sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain; SPTR: Integral membrane sensor signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
   0.898
Sgly_1796
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR008595: IPR011712: IPR003594; KEGG: dhd:Dhaf_2790 sensor DegS domain protein; PFAM: Sensor DegS; Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain; ATPase-like, ATP-binding domain; SPTR: Putative uncharacterized protein; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 0.890
Sgly_0740
Histidine kinase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: dsy:DSY2026 hypothetical protein; PFAM: ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: Putative uncharacterized protein; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
   0.866
Sgly_0838
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: pjd:Pjdr2_1032 histidine kinase; PFAM: ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: Histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
   0.860
Sgly_2230
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660: IPR003661: IPR003594: IPR001789: IPR 008207; KEGG: cth:Cthe_1825 Hpt sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, phosphotransfer (Hpt) domain; SMART: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, d [...]
 
 
 0.841
Sgly_2720
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: dhd:Dhaf_0099 histidine kinase; PFAM: ATPase-like, ATP-binding domain; SPTR: Histidine kinase.
  
   0.816
Sgly_0843
Integral membrane sensor hybrid histidine kinase; COGs: COG5002 Signal transduction histidine kinase; InterPro IPR003661: IPR003594: IPR001789; KEGG: afw:Anae109_2929 PAS/PAC sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response regulator, receiver domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response regulator, receiver domain; SPTR: PAS/PAC sens [...]
 
 0.668
Sgly_3335
COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR001173; KEGG: bca:BCE_3442 glycosyl transferase, group 2 family protein; PFAM: Glycosyl transferase, family 2; SPTR: Glycosyl transferase, group 2; PFAM: Glycosyl transferase family 2.
       0.520
Sgly_3337
ABC-2 type transporter; InterPro IPR013525; KEGG: cno:NT01CX_1312 ABC transporter, permease protein, putative; PFAM: ABC-2 type transporter; SPTR: ABC transporter, permease protein, putative; PFAM: ABC-2 type transporter.
 
     0.476
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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