IMPA1 protein (Enterocytozoon hepatopenaei) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

IMPA1

Importin subunit alpha; Belongs to the importin alpha family. (507 aa)

Predicted Functional Partners:

YRB1

0.946

ANKRD32

0.942

Cbp20

0.908

pim1

0.903

GSP1

0.852

ulp-1

0.835

EHP00_2603

0.827

EHP00_2506

0.827

EHP00_1904

0.827

EHP00_220

0.827

Your Current Organism:

Enterocytozoon hepatopenaei

NCBI taxonomy Id: 646526
Other names: E. hepatopenaei, Enterocytozoon sp. ST-2009a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD32	EHP00_1904	A0A1W0E7P4	A0A1W0E3L4	ANKRD32.	Uncharacterized protein.	0.994
ANKRD32	EHP00_220	A0A1W0E7P4	A0A1W0E6G9	ANKRD32.	Uncharacterized protein.	0.994
ANKRD32	EHP00_2506	A0A1W0E7P4	A0A1W0E2H8	ANKRD32.	Uncharacterized protein.	0.994
ANKRD32	EHP00_2603	A0A1W0E7P4	A0A1W0E2C6	ANKRD32.	Uncharacterized protein.	0.994
ANKRD32	GSP1	A0A1W0E7P4	A0A1W0E3F4	ANKRD32.	GSP1.	0.447
ANKRD32	IMPA1	A0A1W0E7P4	A0A1W0E3X4	ANKRD32.	Importin subunit alpha; Belongs to the importin alpha family.	0.942
ANKRD32	YRB1	A0A1W0E7P4	A0A1W0E3R1	ANKRD32.	YRB1.	0.872
ANKRD32	pim1	A0A1W0E7P4	A0A1W0E3F7	ANKRD32.	Pim1.	0.473
Cbp20	EHP00_1904	A0A1W0E4D2	A0A1W0E3L4	Nuclear cap-binding protein subunit 2.	Uncharacterized protein.	0.471
Cbp20	EHP00_2603	A0A1W0E4D2	A0A1W0E2C6	Nuclear cap-binding protein subunit 2.	Uncharacterized protein.	0.471
Cbp20	GSP1	A0A1W0E4D2	A0A1W0E3F4	Nuclear cap-binding protein subunit 2.	GSP1.	0.863
Cbp20	IMPA1	A0A1W0E4D2	A0A1W0E3X4	Nuclear cap-binding protein subunit 2.	Importin subunit alpha; Belongs to the importin alpha family.	0.908
Cbp20	YRB1	A0A1W0E4D2	A0A1W0E3R1	Nuclear cap-binding protein subunit 2.	YRB1.	0.999
EHP00_1904	ANKRD32	A0A1W0E3L4	A0A1W0E7P4	Uncharacterized protein.	ANKRD32.	0.994
EHP00_1904	Cbp20	A0A1W0E3L4	A0A1W0E4D2	Uncharacterized protein.	Nuclear cap-binding protein subunit 2.	0.471
EHP00_1904	EHP00_220	A0A1W0E3L4	A0A1W0E6G9	Uncharacterized protein.	Uncharacterized protein.	0.812
EHP00_1904	EHP00_2506	A0A1W0E3L4	A0A1W0E2H8	Uncharacterized protein.	Uncharacterized protein.	0.812
EHP00_1904	IMPA1	A0A1W0E3L4	A0A1W0E3X4	Uncharacterized protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.827
EHP00_1904	YRB1	A0A1W0E3L4	A0A1W0E3R1	Uncharacterized protein.	YRB1.	0.532
EHP00_1904	pim1	A0A1W0E3L4	A0A1W0E3F7	Uncharacterized protein.	Pim1.	0.786

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

41

PPI enrichment p-value:

0.00626

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 947

0.75

0.6

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2050

Condensation domain, and Siderophore metabolic process

6 of 24

2.22

4.15

1.96e-09

CL:2053

Condensation domain

5 of 19

2.24

3.71

2.58e-08

CL:2032

ACP-like superfamily, and Fatty acid synthase activity

7 of 113

1.62

2.64

2.58e-08

CL:2081

Ketoacyl-synthetase C-terminal extension, and Enoylreductase

3 of 5

2.6

2.59

1.47e-05

CL:2056

Condensation domain

2 of 12

2.05

0.92

0.0181

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005835

Fatty acid synthase complex

4 of 46

1.76

1.7

0.00021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

7 of 58

1.91

3.87

2.20e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00501

AMP-binding enzyme

5 of 46

1.86

2.38

5.24e-06

PF00668

Condensation domain

4 of 26

2.01

2.19

3.24e-05

PF13193

AMP-binding enzyme C-terminal domain

4 of 37

1.86

1.93

7.91e-05

PF00296

Luciferase-like monooxygenase

2 of 7

2.28

0.97

0.0161

PF00975

Thioesterase domain

2 of 9

2.17

0.92

0.0197

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

7 of 59

1.9

3.54

2.40e-09

IPR009081

Phosphopantetheine binding ACP domain

7 of 59

1.9

3.54

2.40e-09

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

6 of 47

1.93

3.23

3.46e-08

IPR006162

Phosphopantetheine attachment site

5 of 36

1.97

2.76

1.04e-06

IPR020845

AMP-binding, conserved site

5 of 42

1.9

2.6

1.70e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

5 of 29

2.06

3.22

1.24e-07

SM00826

PKS_DH

3 of 15

2.12

1.91

0.00018

SM00825

Beta-ketoacyl synthase

3 of 18

2.05

1.87

0.00019

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

3 of 19

2.02

1.86

0.00019

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

2 of 22

1.78

0.87

0.0194

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