RET1 protein (Enterocytozoon hepatopenaei) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

RET1

DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1089 aa)

Predicted Functional Partners:

EHP00_1947

0.999

RPB10

0.999

NRPB6A

0.999

rpc40

0.999

RPO31

0.999

POLR3F

0.995

rpa1

0.985

rpb3

0.966

EHP00_2178

0.957

EHP00_2418

0.952

Your Current Organism:

Enterocytozoon hepatopenaei

NCBI taxonomy Id: 646526
Other names: E. hepatopenaei, Enterocytozoon sp. ST-2009a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHP00_1947	EHP00_2178	A0A1W0E315	A0A1W0E6V1	DNA-directed RNA polymerase subunit H RpoH-RPB5.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
EHP00_1947	EHP00_2418	A0A1W0E315	A0A1W0E7Y2	DNA-directed RNA polymerase subunit H RpoH-RPB5.	Transcription initiation factor TFIID subunit TAF5.	0.999
EHP00_1947	NRPB6A	A0A1W0E315	A0A1W0E4J8	DNA-directed RNA polymerase subunit H RpoH-RPB5.	NRPB6A.	0.999
EHP00_1947	POLR3F	A0A1W0E315	A0A1W0E5I1	DNA-directed RNA polymerase subunit H RpoH-RPB5.	POLR3F.	0.993
EHP00_1947	RET1	A0A1W0E315	A0A1W0E6Z8	DNA-directed RNA polymerase subunit H RpoH-RPB5.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
EHP00_1947	RPB10	A0A1W0E315	A0A1W0E4H2	DNA-directed RNA polymerase subunit H RpoH-RPB5.	RPB10.	0.999
EHP00_1947	RPO31	A0A1W0E315	A0A1W0E754	DNA-directed RNA polymerase subunit H RpoH-RPB5.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
EHP00_1947	rpa1	A0A1W0E315	A0A1W0E3J9	DNA-directed RNA polymerase subunit H RpoH-RPB5.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
EHP00_1947	rpb3	A0A1W0E315	A0A1W0E4E8	DNA-directed RNA polymerase subunit H RpoH-RPB5.	Rpb3.	0.999
EHP00_1947	rpc40	A0A1W0E315	A0A1W0E676	DNA-directed RNA polymerase subunit H RpoH-RPB5.	Rpc40.	0.999
EHP00_2178	EHP00_1947	A0A1W0E6V1	A0A1W0E315	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit H RpoH-RPB5.	0.999
EHP00_2178	EHP00_2418	A0A1W0E6V1	A0A1W0E7Y2	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Transcription initiation factor TFIID subunit TAF5.	0.999
EHP00_2178	NRPB6A	A0A1W0E6V1	A0A1W0E4J8	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	NRPB6A.	0.999
EHP00_2178	RET1	A0A1W0E6V1	A0A1W0E6Z8	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.957
EHP00_2178	RPB10	A0A1W0E6V1	A0A1W0E4H2	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	RPB10.	0.999
EHP00_2178	rpb3	A0A1W0E6V1	A0A1W0E4E8	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Rpb3.	0.999
EHP00_2178	rpc40	A0A1W0E6V1	A0A1W0E676	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Rpc40.	0.968
EHP00_2418	EHP00_1947	A0A1W0E7Y2	A0A1W0E315	Transcription initiation factor TFIID subunit TAF5.	DNA-directed RNA polymerase subunit H RpoH-RPB5.	0.999
EHP00_2418	EHP00_2178	A0A1W0E7Y2	A0A1W0E6V1	Transcription initiation factor TFIID subunit TAF5.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
EHP00_2418	NRPB6A	A0A1W0E7Y2	A0A1W0E4J8	Transcription initiation factor TFIID subunit TAF5.	NRPB6A.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.901

expected number of edges:

11

PPI enrichment p-value:

0.000451

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

3 of 5

2.28

1.79

0.00041

GO:0033554

Cellular response to stress

6 of 78

1.39

1.47

8.68e-05

GO:0006281

DNA repair

5 of 54

1.47

1.43

0.00026

GO:0009432

SOS response

3 of 15

1.8

1.22

0.0034

GO:0006308

DNA catabolic process

2 of 5

2.1

1.01

0.0128

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004536

Deoxyribonuclease activity

4 of 23

1.74

1.5

0.00063

GO:0008855

Exodeoxyribonuclease VII activity

2 of 2

2.5

1.16

0.0076

GO:0009381

Excinuclease ABC activity

2 of 3

2.33

1.11

0.0090

GO:0140097

Catalytic activity, acting on DNA

5 of 105

1.18

0.88

0.0039

GO:0140640

Catalytic activity, acting on a nucleic acid

6 of 242

0.9

0.63

0.0071

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.32

0.0037

GO:0009380

Excinuclease repair complex

2 of 3

2.33

1.28

0.0041

GO:1902494

Catalytic complex

5 of 80

1.3

1.21

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:617

DNA damage, and UvrD/REP helicase N-terminal domain

3 of 21

1.66

0.72

0.0372

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tor03420

Nucleotide excision repair

3 of 9

2.03

1.66

0.00053

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990391

DNA repair complex

3 of 6

2.2

1.69

0.00058

GOCC:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.14

0.0081

GOCC:0009380

Excinuclease repair complex

2 of 3

2.33

1.11

0.0090

GOCC:1902494

Catalytic complex

5 of 192

0.92

0.6

0.0141

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

5 of 29

1.74

2.22

6.15e-06

KW-0742

SOS response

3 of 10

1.98

1.67

0.00047

KW-0267

Excision nuclease

2 of 3

2.33

1.24

0.0049

KW-0228

DNA excision

2 of 3

2.33

1.24

0.0049

KW-0269

Exonuclease

2 of 15

1.63

0.74

0.0341

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02151

UvrB/uvrC motif

2 of 2

2.5

0.84

0.0295

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 8

1.9

0.7

0.0465

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