STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFM43515.1PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)    
Predicted Functional Partners:
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.996
purC
PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase.
 0.991
AFM41341.1
PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synthase, clade II.
  
  
 0.990
purH
PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
  
 0.987
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.943
adk
Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.940
AFM41799.1
5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Bacterial SH3 domain.
  
 
 0.918
surE
5'-nucleotidase, exopolyphosphatase, 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.916
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase.
    
0.914
AFM39376.1
Aspartate ammonia-lyase; PFAM: Fumarase C C-terminus; Lyase; TIGRFAM: aspartate ammonia-lyase.
     
0.905
Your Current Organism:
Desulfosporosinus acidiphilus
NCBI taxonomy Id: 646529
Other names: D. acidiphilus SJ4, Desulfosporosinus acidiphilus DSM 22704, Desulfosporosinus acidiphilus SJ4, Desulfosporosinus acidiphilus str. SJ4, Desulfosporosinus acidiphilus strain SJ4, Desulfosporosinus sp. SJ4
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