Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH06321.1Manually curated; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like; KEGG: mae:Maeo_0516 anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM. (240 aa)    
Predicted Functional Partners:
AEH06879.1
PFAM: ATP-cone; manually curated; KEGG: mmp:MMP0227 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic.
  
 0.963
AEH06346.1
HAMAP: UPF0200 protein; KEGG: mae:Maeo_0813 hypothetical protein; Belongs to the UPF0200 family.
       0.580
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
       0.561
hisC
PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: mae:Maeo_0250 histidinol-phosphate aminotransferase.
  
  
 0.536
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.499
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
  
 0.485
AEH06320.1
KEGG: mae:Maeo_0515 beta-lactamase domain-containing protein.
       0.484
dacZ
Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
  
  
 0.445
AEH06323.1
KEGG: mae:Maeo_0460 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; Phosphomethylpyrimidine kinase type-1.
     
 0.427
Your Current Organism:
Methanothermococcus okinawensis
NCBI taxonomy Id: 647113
Other names: M. okinawensis IH1, Methanothermococcus okinawensis DSM 14208, Methanothermococcus okinawensis IH1, Methanothermococcus okinawensis str. IH1, Methanothermococcus okinawensis strain IH1
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