node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEH06131.1 | AEH07419.1 | Metok_0135 | Metok_1456 | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: mae:Maeo_0205 asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.806 |
AEH06131.1 | fen | Metok_0135 | Metok_1233 | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: mae:Maeo_0205 asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.474 |
AEH06262.1 | AEH07419.1 | Metok_0270 | Metok_1456 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.457 |
AEH06262.1 | eif2b | Metok_0270 | Metok_1201 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.445 |
AEH06262.1 | fusA | Metok_0270 | Metok_0480 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.952 |
AEH06262.1 | rpl18 | Metok_0270 | Metok_0785 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | Ribosomal protein L18P/L5E; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. | 0.884 |
AEH06262.1 | rpl19e | Metok_0270 | Metok_0784 | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.890 |
AEH07231.1 | AEH07419.1 | Metok_1263 | Metok_1456 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.624 |
AEH07231.1 | dphB | Metok_1263 | Metok_0033 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.902 |
AEH07231.1 | eif2b | Metok_1263 | Metok_1201 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.544 |
AEH07231.1 | fusA | Metok_1263 | Metok_0480 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.992 |
AEH07231.1 | rpl19e | Metok_1263 | Metok_0784 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.471 |
AEH07419.1 | AEH06131.1 | Metok_1456 | Metok_0135 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: mae:Maeo_0205 asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. | 0.806 |
AEH07419.1 | AEH06262.1 | Metok_1456 | Metok_0270 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Shwachman-Bodian-Diamond syndrome protein; KEGG: mae:Maeo_0180 putative RNA-associated protein; TIGRFAM: Ribosome maturation protein SBDS; PFAM: Ribosome maturation protein SBDS, C-terminal; Ribosome maturation protein SBDS, N-terminal. | 0.457 |
AEH07419.1 | AEH07231.1 | Metok_1456 | Metok_1263 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.624 |
AEH07419.1 | dphB | Metok_1456 | Metok_0033 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.758 |
AEH07419.1 | eif2b | Metok_1456 | Metok_1201 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.560 |
AEH07419.1 | fen | Metok_1456 | Metok_1233 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.483 |
AEH07419.1 | fusA | Metok_1456 | Metok_0480 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.971 |
AEH07419.1 | hemC | Metok_1456 | Metok_0592 | KEGG: mmx:MmarC6_0609 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Conserved hypothetical protein CHP00289; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.523 |