| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rvan_0357 | htpX | Rvan_0357 | Rvan_0358 | TIGRFAM: protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: bja:blr3130 serine protease DO-like precursor; SMART: PDZ/DHR/GLGF domain protein; Belongs to the peptidase S1C family. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.493 |
| Rvan_0359 | guaB | Rvan_0359 | Rvan_1102 | Sun protein; KEGG: nwi:Nwi_0156 tRNA and rRNA cytosine-C5-methylase; TIGRFAM: sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.416 |
| Rvan_0359 | htpX | Rvan_0359 | Rvan_0358 | Sun protein; KEGG: nwi:Nwi_0156 tRNA and rRNA cytosine-C5-methylase; TIGRFAM: sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.519 |
| Rvan_0644 | Rvan_2626 | Rvan_0644 | Rvan_2626 | Thioredoxin; KEGG: azc:AZC_4257 thioredoxin precursor; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein. | PFAM: FxsA cytoplasmic membrane protein; KEGG: pde:Pden_2785 FxsA cytoplasmic membrane protein. | 0.754 |
| Rvan_0644 | grpE | Rvan_0644 | Rvan_3456 | Thioredoxin; KEGG: azc:AZC_4257 thioredoxin precursor; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.891 |
| Rvan_0644 | htpX | Rvan_0644 | Rvan_0358 | Thioredoxin; KEGG: azc:AZC_4257 thioredoxin precursor; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.536 |
| Rvan_2312 | htpX | Rvan_2312 | Rvan_0358 | PFAM: protein of unknown function UPF0005; KEGG: pub:SAR11_0291 integral membrane protein; Belongs to the BI1 family. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.517 |
| Rvan_2626 | Rvan_0644 | Rvan_2626 | Rvan_0644 | PFAM: FxsA cytoplasmic membrane protein; KEGG: pde:Pden_2785 FxsA cytoplasmic membrane protein. | Thioredoxin; KEGG: azc:AZC_4257 thioredoxin precursor; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein. | 0.754 |
| Rvan_2626 | grpE | Rvan_2626 | Rvan_3456 | PFAM: FxsA cytoplasmic membrane protein; KEGG: pde:Pden_2785 FxsA cytoplasmic membrane protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.483 |
| Rvan_2626 | htpX | Rvan_2626 | Rvan_0358 | PFAM: FxsA cytoplasmic membrane protein; KEGG: pde:Pden_2785 FxsA cytoplasmic membrane protein. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.519 |
| ftsH | grpE | Rvan_0567 | Rvan_3456 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.410 |
| ftsH | htpX | Rvan_0567 | Rvan_0358 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.647 |
| ftsH-2 | grpE | Rvan_3296 | Rvan_3456 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.410 |
| ftsH-2 | htpX | Rvan_3296 | Rvan_0358 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.647 |
| grpE | Rvan_0644 | Rvan_3456 | Rvan_0644 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Thioredoxin; KEGG: azc:AZC_4257 thioredoxin precursor; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein. | 0.891 |
| grpE | Rvan_2626 | Rvan_3456 | Rvan_2626 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: FxsA cytoplasmic membrane protein; KEGG: pde:Pden_2785 FxsA cytoplasmic membrane protein. | 0.483 |
| grpE | ftsH | Rvan_3456 | Rvan_0567 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.410 |
| grpE | ftsH-2 | Rvan_3456 | Rvan_3296 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.410 |
| grpE | guaB | Rvan_3456 | Rvan_1102 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.488 |
| grpE | htpX | Rvan_3456 | Rvan_0358 | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | PFAM: peptidase M48 Ste24p; KEGG: rpt:Rpal_0855 heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.573 |
