Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Rvan_0453PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: rpb:RPB_3873 putative 6-pyruvoyl tetrahydropterin synthase. (118 aa)    
Predicted Functional Partners:
queE
Hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.996
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.979
folE
TIGRFAM: GTP cyclohydrolase I; KEGG: hba:Hbal_2379 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase.
  
 
 0.972
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.907
Rvan_1563
KEGG: hne:HNE_3483 alkaline phosphatase; PFAM: Alkaline phosphatase; SMART: Alkaline phosphatase; Belongs to the alkaline phosphatase family.
     
  0.900
cysS
TIGRFAM: cysteinyl-tRNA synthetase; KEGG: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.577
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.521
Rvan_0450
KEGG: rxy:Rxyl_2315 nitrile hydratase, alpha subunit; PFAM: Nitrile hydratase alpha chain.
       0.490
Rvan_0451
Hypothetical protein; KEGG: rxy:Rxyl_2314 putative ScnA-like protein.
       0.490
Rvan_0452
KEGG: dsh:Dshi_1847 hypothetical protein.
       0.490
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.