STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rvan_0633DNA ligase D; KEGG: mes:Meso_1150 ATP dependent DNA ligase; TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; DNA primase small subunit. (970 aa)    
Predicted Functional Partners:
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.989
Rvan_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.974
Rvan_0266
KEGG: exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
 
 
 0.964
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.937
Rvan_2184
KEGG: bmt:BSUIS_A1844 exodeoxyribonuclease III (xth); TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase.
 
 
 0.830
Rvan_2150
PFAM: protein of unknown function DUF72; KEGG: azc:AZC_0328 hypothetical protein.
 
    0.799
Rvan_2096
KEGG: amc:MADE_00669 RNA procession exonuclease-like protein.
 
 0.776
Rvan_2420
Hypothetical protein; KEGG: pzu:PHZ_c3267 nucleotidyltransferase/DNA polymerase involved in DNA repair.
  
 
 0.741
Rvan_1986
PFAM: protein of unknown function DUF892; KEGG: rpb:RPB_1737 hypothetical protein.
 
     0.734
Rvan_1896
KEGG: avi:Avi_3946 exonuclease protein.
   
 0.683
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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