Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Rvan_0983PFAM: nickel-dependent hydrogenase large subunit; KEGG: azo:azo3808 ferredoxin hydrogenase, large subunit. (485 aa)    
Predicted Functional Partners:
Rvan_0982
PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: azl:AZL_a10680 nickel-dependent hydrogenase small subunit.
 0.999
Rvan_0964
TIGRFAM: hydrogenase (NiFe) small subunit HydA; KEGG: reh:PHG001 membrane-bound [NiFe] hydrogenase small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit.
 0.997
Rvan_0981
PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; KEGG: PAS/PAC sensor signal transduction histidine kinase; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; histidine kinase A domain protein.
 
 
 0.994
Rvan_0974
KEGG: mgm:Mmc1_2497 Ni,Fe-hydrogenase I large subunit.
 
 
0.970
Rvan_0967
TIGRFAM: Ni/Fe-hydrogenase, b-type cytochrome subunit; KEGG: Ni/Fe-hydrogenase, b-type cytochrome subunit.
 
 
 0.965
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.942
Rvan_0965
PFAM: nickel-dependent hydrogenase large subunit; KEGG: azo:azo3787 ferredoxin hydrogenase, large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
  
 
0.926
Rvan_0592
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mag:amb3375 putative glutamate synthase (NADPH) small subunit.
    
 0.915
Rvan_0984
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 
 0.907
Rvan_0599
TIGRFAM: sulfite reductase, dissimilatory-type beta subunit; KEGG: aeh:Mlg_1654 sulfite reductase, dissimilatory-type beta subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein.
     
 0.902
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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