STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rvan_1127Homocitrate synthase; KEGG: rpd:RPD_1086 alpha-isopropylmalate/homocitrate synthase; TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (427 aa)    
Predicted Functional Partners:
Rvan_1670
KEGG: msl:Msil_0137 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.925
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.922
Rvan_0023
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: azl:AZL_023130 acetyl-CoA C-acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
Rvan_0557
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: rce:RC1_1744 3-ketoacyl-CoA thiolase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
Rvan_0850
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: maq:Maqu_2016 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
Rvan_3408
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: tmz:Tmz1t_0732 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.913
Rvan_3597
acetate/CoA ligase; KEGG: rsq:Rsph17025_0782 acetate--CoA ligase; TIGRFAM: acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase.
  
 
 0.913
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.912
Rvan_1914
TIGRFAM: malate synthase A; KEGG: pzu:PHZ_c3212 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family.
   
 
 0.907
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.