Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Rvan_1709KEGG: dac:Daci_2539 peptidase S24/S26 domain-containing protein. (162 aa)    
Predicted Functional Partners:
Rvan_1708
Helix-turn-helix domain protein; KEGG: pzu:PHZ_c2222 hypothetical protein; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein.
      0.921
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.917
Rvan_2420
Hypothetical protein; KEGG: pzu:PHZ_c3267 nucleotidyltransferase/DNA polymerase involved in DNA repair.
  
 
 0.680
Rvan_2106
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.552
Rvan_1710
PFAM: CoA-binding domain protein; KEGG: mlo:mlr8464 hypothetical protein.
       0.507
Rvan_1711
PFAM: protein of unknown function DUF185; KEGG: azc:AZC_3983 hypothetical protein.
       0.500
Rvan_1712
PFAM: protein of unknown function DUF152; KEGG: pla:Plav_2260 hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.
       0.488
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.462
Rvan_0015
Transcriptional regulator, AraC family; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; Ada metal-binding domain-containing protein; helix-turn-helix- domain containing protein AraC type; methylguanine DNA methyltransferase ribonuclease domain protein; KEGG: mpo:Mpop_4835 transcriptional regulator, AraC family; SMART: Helix-turn-helix, AraC domain.
  
  
 0.433
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
  
 0.427
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.