Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (284 aa)    
Predicted Functional Partners:
speH
S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 0.999
Rvan_1802
PFAM: Spermine synthase; KEGG: xau:Xaut_2119 spermine synthase.
  
  
  0.954
Rvan_0777
N-carbamoylputrescine amidase; KEGG: pzu:PHZ_c0325 hydrolase, carbon-nitrogen family; TIGRFAM: N-carbamoylputrescine amidase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase.
  
 
 0.930
Rvan_2299
PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
 0.925
mtnP
Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
  
 
 0.922
Rvan_0950
Diamine N-acetyltransferase; KEGG: lwe:lwe0009 spermidine N1-acetyltransferase; PFAM: GCN5-related N-acetyltransferase.
    
 0.906
Rvan_1712
PFAM: protein of unknown function DUF152; KEGG: pla:Plav_2260 hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.901
Rvan_2083
PFAM: aminotransferase class-III; KEGG: cag:Cagg_2915 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
Rvan_2683
Acyl-homoserine-lactone synthase; KEGG: aav:Aave_3811 autoinducer synthesis protein; PFAM: autoinducer synthesis protein.
     
  0.900
Rvan_1981
PFAM: MaoC domain protein dehydratase; KEGG: azo:azo0191 hypothetical protein.
       0.773
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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