Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Rvan_1989TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: mag:amb0607 monomeric isocitrate dehydrogenase; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (744 aa)    
Predicted Functional Partners:
Rvan_1988
Aconitate hydratase 2; KEGG: mag:amb4400 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; TIGRFAM: aconitate hydratase 2; PFAM: Aconitase B; aconitate hydratase domain-containing protein; Belongs to the aconitase/IPM isomerase family.
  
 
 0.966
Rvan_1154
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 
 0.950
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
  
 0.943
Rvan_0651
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: xau:Xaut_0156 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component.
   
 
 0.918
Rvan_0147
4Fe-4S ferredoxin, iron-sulfur binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
  
  
 0.894
Rvan_1644
KEGG: xau:Xaut_0477 glutamate synthase (ferredoxin); PFAM: glutamine amidotransferase class-II; glutamate synthase; ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein.
     
 0.892
Rvan_0809
KEGG: mno:Mnod_7577 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
  0.842
Rvan_0350
PFAM: NAD-glutamate dehydrogenase; KEGG: NAD-glutamate dehydrogenase.
   
 
 0.818
argH
KEGG: pla:Plav_1602 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase.
    
 0.811
Rvan_1643
KEGG: bid:Bind_3032 glutamate synthase subunit beta; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
   
 
 0.808
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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