Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa)    
Predicted Functional Partners:
Rvan_2218
Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
 
 0.996
Rvan_2220
PFAM: Phosphoglycerate mutase; KEGG: dar:Daro_0151 phosphoglycerate/bisphosphoglycerate mutase.
 
 
 0.996
Rvan_1117
Cobalbumin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
 
 
 0.990
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.929
cobQ-2
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.928
Rvan_3506
TIGRFAM: ATP/cobalamin adenosyltransferase; KEGG: mpo:Mpop_1702 ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; Lipid A 3-O-deacylase-related; Belongs to the Cob(I)alamin adenosyltransferase family.
    
 0.926
Rvan_3659
TIGRFAM: precorrin-3B C17-methyltransferase; KEGG: bra:BRADO4903 precorrin-3B C(17)-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
  
  
 0.914
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
   
 0.870
Rvan_3658
TIGRFAM: precorrin-6x reductase; KEGG: bra:BRADO4902 precorrin-6A reductase; PFAM: Precorrin-6x reductase CbiJ/CobK.
  
  
 0.786
Rvan_3657
TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; KEGG: bbt:BBta_3150 precorrin-6Y C5,15-methyltransferase (decarboxylating); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
  
  
 0.729
Your Current Organism:
Rhodomicrobium vannielii
NCBI taxonomy Id: 648757
Other names: R. vannielii ATCC 17100, Rhodomicrobium vannielii ATCC 17100, Rhodomicrobium vannielii NCIMB 10020, Rhodomicrobium vannielii str. ATCC 17100, Rhodomicrobium vannielii strain ATCC 17100
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