| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rvan_0917 | lon-2 | Rvan_0917 | Rvan_2706 | PFAM: protein of unknown function DUF1150; KEGG: oca:OCAR_4463 hypothetical protein. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.709 |
| Rvan_1483 | Rvan_2707 | Rvan_1483 | Rvan_2707 | KEGG: sfu:Sfum_3853 hypothetical protein. | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | 0.572 |
| Rvan_1483 | dnaJ | Rvan_1483 | Rvan_2315 | KEGG: sfu:Sfum_3853 hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.796 |
| Rvan_1483 | dnaK | Rvan_1483 | Rvan_2314 | KEGG: sfu:Sfum_3853 hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.972 |
| Rvan_1483 | groL | Rvan_1483 | Rvan_2853 | KEGG: sfu:Sfum_3853 hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.976 |
| Rvan_1483 | grpE | Rvan_1483 | Rvan_3456 | KEGG: sfu:Sfum_3853 hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.843 |
| Rvan_1483 | hslU | Rvan_1483 | Rvan_2011 | KEGG: sfu:Sfum_3853 hypothetical protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.896 |
| Rvan_1483 | hslV | Rvan_1483 | Rvan_2012 | KEGG: sfu:Sfum_3853 hypothetical protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.902 |
| Rvan_1483 | lon-2 | Rvan_1483 | Rvan_2706 | KEGG: sfu:Sfum_3853 hypothetical protein. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.701 |
| Rvan_2707 | Rvan_1483 | Rvan_2707 | Rvan_1483 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | KEGG: sfu:Sfum_3853 hypothetical protein. | 0.572 |
| Rvan_2707 | dnaK | Rvan_2707 | Rvan_2314 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.566 |
| Rvan_2707 | grpE | Rvan_2707 | Rvan_3456 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.561 |
| Rvan_2707 | hslU | Rvan_2707 | Rvan_2011 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.518 |
| Rvan_2707 | hslV | Rvan_2707 | Rvan_2012 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.535 |
| Rvan_2707 | lon-2 | Rvan_2707 | Rvan_2706 | KEGG: swi:Swit_1147 molecular chaperone (small heat shock protein)-like protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.852 |
| clpX | dnaJ | Rvan_0334 | Rvan_2315 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.438 |
| clpX | dnaK | Rvan_0334 | Rvan_2314 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.594 |
| clpX | groL | Rvan_0334 | Rvan_2853 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.786 |
| clpX | grpE | Rvan_0334 | Rvan_3456 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.522 |
| clpX | hslU | Rvan_0334 | Rvan_2011 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.739 |
