STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU96371.1Phosphodiesterase, MJ0936 family; KEGG: trq:TRQ2_0718 phosphodiesterase; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase. (161 aa)    
Predicted Functional Partners:
ADU96284.1
Ankyrin; KEGG: pmx:PERMA_0371 MHC_I C-terminus family protein; PFAM: Ankyrin; SMART: Ankyrin.
    
 
 0.843
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.817
ADU96106.1
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.796
ADU96370.1
Hypothetical protein; KEGG: swo:Swol_2452 carbonic anhydrase-like protein.
       0.786
ADU96369.1
Diguanylate cyclase/phosphodiesterase with extracellular sensor; TIGRFAM: diguanylate cyclase; PFAM: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein; KEGG: saf:SULAZ_1249 diguanylate cyclase/phosphodiesterase; SMART: EAL domain protein; GGDEF domain containing protein; histidine kinase HAMP region domain protein.
       0.682
ADU96861.1
KEGG: gsu:GSU1581 polyA polymerase family protein; PFAM: Polynucleotide adenylyltransferase region; CBS domain containing protein; phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SMART: CBS domain containing protein; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
 
 0.547
ADU96373.1
PFAM: Conserved TM helix repeat-containing protein; KEGG: pcr:Pcryo_2407 TM helix protein.
       0.545
Your Current Organism:
Thermovibrio ammonificans
NCBI taxonomy Id: 648996
Other names: T. ammonificans HB-1, Thermovibrio ammonificans DSM 15698, Thermovibrio ammonificans HB-1, Thermovibrio ammonificans str. HB-1, Thermovibrio ammonificans strain HB-1
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