STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lbys_0129COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR013520:IPR001357:IPR006055; KEGG: cpe:CPE1401 DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III; BRCT domain protein; SMART: Exonuclease; SPTR: Probable DNA polymerase III epsilon chain; PFAM: Exonuclease; BRCA1 C Terminus (BRCT) domain. (303 aa)    
Predicted Functional Partners:
Lbys_2252
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.977
Lbys_1156
COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR004805:IPR 003141; KEGG: sli:Slin_0531 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc).
  
 0.962
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.960
Lbys_3029
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: sli:Slin_6089 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunits-like protein; TIGRFAM: DNA polymerase III, delta' subunit.
  
 0.960
Lbys_1021
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790; KEGG: sli:Slin_1937 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.953
Lbys_3145
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006055:IPR013520; KEGG: bfs:BF1141 putative exonuclease; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; SPTR: DNA polymerase III, epsilon subunit; PFAM: Exonuclease.
 
  
0.919
Lbys_2788
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006055:IPR013520; KEGG: dfe:Dfer_3900 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; SPTR: DNA polymerase III, epsilon subunit; PFAM: Exonuclease.
 
  
 0.917
Lbys_1677
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212:IPR014016:IPR014017; KEGG: sli:Slin_5601 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: UvrD/REP helicase; PFAM: UvrD/REP helicase.
  
  
 0.886
Lbys_0128
Hypothetical protein.
       0.773
Lbys_3143
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR001678; KEGG: sli:Slin_5890 Fmu (Sun) domain protein; PFAM: Fmu (Sun) domain protein; SPTR: Fmu (Sun) domain protein; PFAM: NOL1/NOP2/sun family.
 
   0.755
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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