STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lbys_0179COGs: COG4646 DNA methylase; InterPro IPR003356:IPR001650:IPR002296; KEGG: pgn:PGN_0086 putative DNA methylase; PFAM: N-6 DNA methylase; helicase domain protein; SMART: helicase domain protein; SPTR: Probable DNA methylase; PFAM: N-6 DNA Methylase; Helicase conserved C-terminal domain; SNF2 family N-terminal domain. (1805 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.889
Lbys_2252
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.879
Lbys_0118
Restriction modification system DNA specificity domain; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: sli:Slin_3089 restriction modification system DNA specificity domain protein; PFAM: restriction modification system DNA specificity domain; SPTR: Restriction modification system DNA specificity domain protein; PFAM: Type I restriction modification DNA specificity domain.
  
 
 0.868
Lbys_1356
Restriction modification system DNA specificity domain; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: cte:CT1880 type I restriction system specificity protein; PFAM: restriction modification system DNA specificity domain; SPTR: Putative uncharacterized protein; PFAM: Type I restriction modification DNA specificity domain.
  
 
 0.868
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.847
Lbys_0176
InterPro IPR005094; KEGG: fjo:Fjoh_3018 relaxase/mobilization nuclease family protein; PFAM: Relaxase/mobilization nuclease family protein; SPTR: Relaxase/mobilization nuclease family protein; PFAM: Relaxase/Mobilisation nuclease domain.
 
 
 0.846
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.842
Lbys_1354
Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification.
  
  
 0.829
Lbys_0184
DNA topoisomerase III; COGs: COG0550 Topoisomerase IA; InterProIPR018089:IPR005738:IPR006171:IPR013497:IPR 000380:IPR006154:IPR003601:IPR003602; KEGG: fjo:Fjoh_3021 DNA topoisomerase; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain-containing protein; PRIAM: DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain-containing protein; SPTR: DNA topoisomerase; TIGRFAM: DNA topoisomerase III; PFAM: Toprim domain; DNA topoisomerase; TIGRFAM: DNA topoisomerase III, bacteria and conjugative plasmid.
 
 
 0.828
Lbys_0180
Domain of unknown function DUF1896; InterPro IPR015082; KEGG: bth:BT_2325 hypothetical protein; PFAM: Domain of unknown function DUF1896; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1896).
  
    0.824
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.