STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Lbys_0747Chorismate binding protein; COGs: COG1169 Isochorismate synthase; InterPro IPR015890; KEGG: sli:Slin_0770 chorismate binding-like protein; PFAM: Chorismate binding-like; SPTR: Chorismate binding-like protein; PFAM: chorismate binding enzyme. (383 aa)    
Predicted Functional Partners:
menD-2
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
 
 0.984
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene -1-carboxylic-acidsynthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
 
 0.983
Lbys_0057
Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR010957:IPR020822:IPR001086:IPR 008242:IPR002701; KEGG: sli:Slin_2566 chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase, type II; SPTR: Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of proteobacterial P-protein, clade 2.
 
 
 0.925
Lbys_2174
COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR006220:IPR011702:IPR001317:IPR006221:IPR 000991:IPR017926; KEGG: sli:Slin_5473 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
  
 
  0.921
Lbys_0765
DAHP synthetase I/KDSA; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR002701:IPR006218:IPR020822; KEGG: dfe:Dfer_4394 DAHP synthetase I/KdsA; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; SPTR: DAHP synthetase I/KDSA; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: chorismate mutase related enzymes; phospho-2-dehydro-3-deoxyheptonate aldolase.
  
 
 0.902
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.891
Lbys_2173
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999:IPR006805:IPR015890; KEGG: dfe:Dfer_3790 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: Anthranilate synthase; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme.
  
  
0.877
Lbys_0734
O-succinylbenzoic acid (OSB) synthetase; COGs: COG4948 L-alanine-DL-glutamate epimerase; InterPro IPR010196:IPR018110:IPR013342; KEGG: cat:CA2559_11263 chloromuconate cycloisomerase; PFAM: Mandelate racemase/muconate lactonizing protein; SPTR: Chloromuconate cycloisomerase; TIGRFAM: o-succinylbenzoic acid (OSB) synthetase; PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; TIGRFAM: o-succinylbenzoic acid (OSB) synthetase.
 
   
 0.811
Lbys_1329
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: sli:Slin_1750 O-succinylbenzoic acid--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: O-succinylbenzoic acid--CoA ligase; PFAM: AMP-binding enzyme.
 
   
 0.809
Lbys_2637
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838:IPR001176:IPR004839; KEGG: dfe:Dfer_3724 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; PFAM: Aminotransferase class I and II.
    
  0.805
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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