STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lbys_0789Bifunctional deaminase-reductase domain protein; COGs: COG0262 Dihydrofolate reductase; InterPro IPR002734; KEGG: fba:FIC_01203 bifunctional deaminase-reductase domain protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: Bifunctional deaminase-reductase domain protein; PFAM: RibD C-terminal domain. (177 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.890
Lbys_0788
Helix-turn-helix, AraC domain; COGs: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; InterPro IPR018060; KEGG: fba:FIC_01204 putative transcriptional regulator, AraC family; SMART: Helix-turn-helix, AraC domain; SPTR: Putative transcriptional regulator, AraC family; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family.
 
     0.776
gcvP
Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.594
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
    
 0.544
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.543
Lbys_0928
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR018109:IPR013221; KEGG: dfe:Dfer_1048 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.542
Lbys_0790
Hypothetical protein; KEGG: eba:ebD46 putative transposase; SPTR: Putative uncharacterized protein.
  
    0.460
Lbys_0791
IS66 Orf2 family protein; InterPro IPR008878; KEGG: zpr:ZPR_3984 transposase orf1, IS66 family protein; PFAM: IS66 Orf2 family protein; SPTR: Transposition helper protein; PFAM: IS66 Orf2 like protein.
       0.444
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.