Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
Lbys_0928FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR018109:IPR013221; KEGG: dfe:Dfer_1048 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (428 aa)    
Predicted Functional Partners:
Lbys_1609
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR006390; KEGG: fjo:Fjoh_3497 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Putative dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase.
 
 0.997
Lbys_1116
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: chu:CHU_2468 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase); PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inediphosphokinase(7,8-dihydro-6-hydroxymethylpterin-pyrop hosphokinase); TIGRFAM:2-amino-4-hydroxy-6-hydrox [...]
  
 0.966
Lbys_2007
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.909
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.842
Lbys_0932
Tetratricopeptide TPR_1 repeat-containing protein; InterPro IPR019734:IPR013026:IPR001440:IPR011716; KEGG: sli:Slin_2038 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; Tetratricopeptide TPR_3 repeat-containing protein; SPTR: TPR repeat-containing protein.
  
    0.828
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
       0.821
Lbys_0929
KEGG: sli:Slin_1995 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.821
Lbys_0930
Sporulation domain-containing protein; InterPro IPR007730; KEGG: gfo:GFO_3253 hypothetical protein; PFAM: Sporulation domain-containing protein; SPTR: Putative uncharacterized protein; PFAM: Sporulation related domain.
       0.818
Lbys_0931
KEGG: sli:Slin_2039 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.818
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR001474:IPR018234:IPR020602; KEGG: chu:CHU_0955 GTP cyclohydrolase; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
 
  
 0.677
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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