STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (344 aa)    
Predicted Functional Partners:
Lbys_1279
Uncharacterized protein family UPF0093; COGs: COG1981 membrane protein; InterPro IPR005265:IPR014351; KEGG: phe:Phep_3443 hypothetical protein; PFAM: Uncharacterised protein family UPF0093; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: conserved hypothetical integral membrane protein.
 
  
 0.952
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.928
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.921
Lbys_0733
COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260:IPR018375; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; PFAM: Coproporphyrinogen III oxidase.
 
  
 0.811
Lbys_2292
Major facilitator superfamily MFS_1; COGs: COG2814 Arabinose efflux permease; InterPro IPR005829:IPR001958:IPR011701; KEGG: lic:LIC12361 permease; PFAM: major facilitator superfamily MFS_1; SPTR: Tetracycline resistance protein; PFAM: Major Facilitator Superfamily; TIGRFAM: Multidrug resistance protein.
 
      0.792
Lbys_2015
KEGG: sli:Slin_1179 putative lipoprotein; SPTR: Putative lipoprotein.
       0.709
clpP
ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
    
 0.663
Lbys_2827
COGs: COG1250 3-hydroxyacyl-CoA dehydrogenase; InterPro IPR006176:IPR006108:IPR001753; KEGG: sli:Slin_4424 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; Enoyl-CoA hydratase/isomerase; SPTR: 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; PFAM: Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
  
 
 0.597
Lbys_0744
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
  
 0.558
Lbys_0075
Aconitase; COGs: COG1048 Aconitase A; InterPro IPR018136:IPR006248:IPR001030:IPR000573; KEGG: sli:Slin_2025 aconitate hydratase; PFAM: aconitate hydratase domain-containing protein; SPTR: Aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, mitochondrial.
    
 0.555
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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